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METHOD FOR PRODUCING OPTICALLY ACTIVE OXINDOLE COMPOUND AND TRIAZOLIUM SALT USED THEREIN AS CATALYST コモンズ

外国特許コード F160008733
整理番号 NU-651
掲載日 2016年4月28日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP054960
国際公開番号 WO 2016133217
国際出願日 平成28年2月19日(2016.2.19)
国際公開日 平成28年8月25日(2016.8.25)
優先権データ
  • 特願2015-032106 (2015.2.20) JP
発明の名称 (英語) METHOD FOR PRODUCING OPTICALLY ACTIVE OXINDOLE COMPOUND AND TRIAZOLIUM SALT USED THEREIN AS CATALYST コモンズ
発明の概要(英語) The present invention is able to provide a method for stereoselectively introducing an amino group having various substituents into the α-position of an oxindole compound by a single step by having a specific compound (a carbonyl compound such as an oxindole compound) and a specific hydroxyl amine compound or hydrogen peroxide react with each other in the presence of a specific triazolium salt and a specific trihalogenated acetonitrile compound without undergoing a reaction for reductively breaking a nitrogen-nitrogen bond, a nitrogen-oxygen bond or the like of the product. In addition, an amino group having various substituents is able to be stereoselectively introduced into the α-position of another substrate by a single step by means of a similar reaction mechanism. It is preferable that this reaction is carried out in the presence of a base.
従来技術、競合技術の概要(英語) BACKGROUND ART
Optically active oxindole derivatives (in particular, 3 - position is an amino group substituted oxindole derivatives) is, AG-041R, such as cartellin C as a partial structure of the bioactive agent present, agrochemical products are intermediates for synthesis of the surgeon are widely used. In recent years, the development of more sophisticated pharmaceutical derivatives for the purpose, α-position of the oxindole derivatives having an asymmetric carbon has been desired.
Such a tetra - substituted oxindole derivative having an asymmetric carbon as the synthesis method, such as a particular oxindole derivatives of α - stereoselective electrophilic amination reaction method is known. In the reductive amination reaction with an amination agent may include α -, conventionally, azodicarboxylic acid ester, nitroso compounds, azide and the like may be used yojinan (for example, such as non-patent document 1-4).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
  • 発明者(英語)
  • OOI TAKASHI
  • OHMATSU KOHSUKE
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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