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NON-CANCEROUS LIVER FACTOR USEFUL IN DIAGNOSIS RELATING TO HEPATOCELLULAR CARCINOMA AND UTILIZATION THEREOF コモンズ

外国特許コード F160008736
整理番号 NU-654
掲載日 2016年4月28日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP054939
国際公開番号 WO 2016133212
国際出願日 平成28年2月19日(2016.2.19)
国際公開日 平成28年8月25日(2016.8.25)
優先権データ
  • 特願2015-030710 (2015.2.19) JP
発明の名称 (英語) NON-CANCEROUS LIVER FACTOR USEFUL IN DIAGNOSIS RELATING TO HEPATOCELLULAR CARCINOMA AND UTILIZATION THEREOF コモンズ
発明の概要(英語) Provided are a marker useful in diagnosis such as prognosis prediction or the like of hepatocellular carcinoma, and utilization thereof. The present teaching is a method for assisting diagnosis relating to prognosis prediction or the like of hepatocellular carcinoma, the method comprising a step for measuring the expression levels of the FAM3B (family with sequence similarity 3, member B) gene and/or the KRT23 (keratin 23 (histone deacetylase inducible)) gene. Useful information that assists diagnosis relating to prognosis prediction or the like of hepatocellular carcinoma can be obtained by measuring the expression levels of the FAM3B and/or KRT23 genes in the non-cancerous liver of an individual with a risk of hepatocellular carcinoma or an individual suffering from hepatocellular carcinoma.
従来技術、競合技術の概要(英語) BACKGROUND ART
(Hepatocellular carcinoma,HCC) is hepatocellular carcinoma, liver cell is derived from a malignant tumor. In addition, hepatocellular carcinoma, 95% chronic liver disease such as cirrhosis is a characteristic is associated with. Hepatocellular carcinoma, primary hepatocellular carcinoma and metastatic hepatocellular carcinoma but, in this specification, and unless otherwise specified, when referred to hepatocellular carcinoma, refers to a primary hepatocellular carcinoma.
Hepatocellular carcinoma is, at a high rate in the multi-central known oncogenes. That is, one liver of 1 from the next in the occurrence of hepatocellular carcinoma. For this reason, in hepatocellular carcinoma, even after the surgery, multiple liver tend to relapse, recurrence lesions, lesions in liver metastasis (IM) starting than, multi-center developmental (MO) and frequently (approximately 75%) (non-patent document 1) are. Therefore, in hepatocellular carcinoma, carcinogenesis or a multi-center multi-central and developmental predicting recurrence, prevention or treatment course can be achieved by setting is important.
In the treatment of hepatocellular carcinoma, in general, cancer tissues excised (HCCs) based on pathological examination by the degree of malignancy of cells, prognosis of cancer after surgery is being considered. In addition, tumor markers include AFP of hepatocellular carcinoma (α - fetoprotein), and AFP-L3% PIVKA-II is used.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
  • 発明者(英語)
  • NOMOTO SHUJI
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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