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STRESS-RESISTANCE-IMPARTING COMPOSITION, METHOD FOR IMPARTING STRESS RESISTANCE, STRESS RESISTANCE IN-VIVO BREEDING METHOD, AND STRESS EVALUATION METHOD meetings

Foreign code F160008774
File No. H26-018PCT
Posted date Jul 7, 2016
Country WIPO
International application number 2016JP059169
International publication number WO 2016152911
Date of international filing Mar 23, 2016
Date of international publication Sep 29, 2016
Priority data
  • P2015-059490 (Mar 23, 2015) JP
Title STRESS-RESISTANCE-IMPARTING COMPOSITION, METHOD FOR IMPARTING STRESS RESISTANCE, STRESS RESISTANCE IN-VIVO BREEDING METHOD, AND STRESS EVALUATION METHOD meetings
Abstract A stress resistance-imparting composition from which compositions for imparting stress resistance against insects are provided, and related applications are provided is used to impart stress resistance against insects, wherein said stress resistance-imparting composition contains an N-acetyl tyrosine compound and/or derivative thereof.
Outline of related art and contending technology BACKGROUND ART
From the conventional, high in commercial value of the insects, by receiving the stress from the outside, the productivity of the insects and diminish the commercial value has been regarded as a problem.
For example, like a bee and western silkworm producing insects, as well as, such as stag beetle and insects is itself used as products, low resistance to high temperature (thermal stress) is known. Therefore, the insects when transported to the high temperatures, and the productivity of the insects to prevent the decrease in commercial value, temperature control and a huge cost required to grow while, its effect is limited and the discharge, low cost-effective has been reduced. In addition, the insects, chemicals such as agricultural chemicals and solvent contact by (drug stress), the system can be easily weakened damage also known.
For this reason, with respect to the insects, the stress tolerance in a simple manner, been strongly desired. For this reason, conventionally, the stress resistance of the insects mechanism (anti-stress mechanism) studies have been conducted.
For example, in the related art, parasitic Suma infested mythimna separata moth (Cotesia kariyai) to the mortality of the larvae, a bacterium of the genus Serratia (Serratia marcescens) is markedly increased by the fact that the infection has been known. Of the toxicity of secreting metalloproteaselikeinsecticide (MPLI) Serratia, moth larvae mythimna separata the hemolymph and brain dopamine concentration in the brain of the system increases due to increased apoptosis of cells from a knowledge, prior to the secretion of MPL1, 3 - by injection into the moth larvae mythimna separata iodotyrosine, moth larvae mortality and increased dopamine mythimna separata is suppressed is confirmed (see non-patent document 1).
In addition, for example, in the related art, thermal stress in the load system, lacking Drosophila (Drosophilavirilis) 147 system corresponding to the cross-stress, than the normal wild type strain (101 system) DOPA, dopamine, octopamine, and tyrosine having a higher concentration of is, the stress load does not change has been confirmed. In addition, both constant and tyramine concentration, of the chromosome 6 gene also has been implicated in the lack of stress response also been identified (see non-patent document 2 and 3).
In addition, for example, in the related art, mealworm larvae (high temperature, low temperature, oxidation or the like) various stress and load, stress in the brain or the blood of all of the dopamine-like increase in the concentration of the biogenic amine-like material is confirmed. This material is, in correlation with a mortality rate of larvae, a concentration of about 10/pmole 24 reaches the brain within substantially all died and it was confirmed that, as a result of analysis in fragments, C9 H11 NO5 、213 the structure in which the expected molecular weight is disclosed (see non-patent document 4).
In addition, for example, in the related art, octopamine (OA: tyrosine decarboxylase body) is, in the primary monoamine type insect body as a neurotransmitter, stress load, insect pests of the red flour beetle (Tribolium castaneum Herbst) OA content is increased, inhibited the growth of larvae has been confirmed. The agricultural chemicals include chlorodimephosphole OA-acting and (CDM), this is, the demethylated DCDM CDM N- is to act as an agonist OA is, sensitive adenylate cyclase activation (AC) OA, via increased cAMP vQlb action and the like as claimed in claim is. Other, as an example of the agonist OA, NC-7, AC-6, and HSO-786 has been known (see non-patent document 5).
However, the stress resistance to insects such as the active ingredient can be provided, yet not specifically identified. Therefore, the stress resistance to insects in such compositions are applied, are not found at present. In addition, the composition is used in this way, the stress resistance of the insects and a method of enhancing, in response to the insects of various stress such as a method for evaluating the resistance associated with stress resistance but also expected to be applied in a wide range, this cannot be realized without yet have not yet been accomplished.
Scope of claims (In Japanese)[請求項1]
昆虫類にストレス耐性を付与するためのストレス耐性付与組成物であって、
N-アセチルチロシン化合物及び/又はその誘導体を含むことを特徴とする
ストレス耐性付与組成物。
[請求項2]
請求項1に記載のストレス耐性付与組成物において、
前記ストレス耐性が、温度抵抗性、薬剤抵抗性、感染抵抗性、寄生抵抗性、及び傷害抵抗性から成る群より選択される少なくとも1つの抵抗性であることを特徴とする
ストレス耐性付与組成物。
[請求項3]
請求項1又は請求項2に記載のストレス耐性付与組成物において、
前記ストレス耐性が、抗酸化酵素の活性を制御することによって付与されることを特徴とする
ストレス耐性付与組成物。
[請求項4]
請求項1~請求項3のいずれかに記載のストレス耐性付与組成物において、
前記昆虫類が、アワヨトウ、ハスモンヨトウ、カイコ、キイロショウジョウバエ、ミツバチ、クワガタ、及びカブトムシから成る群より選択されることを特徴とする
ストレス耐性付与組成物。
[請求項5]
請求項1~請求項4のいずれかに記載のストレス耐性付与組成物を前記昆虫類に導入する導入工程を含むことを特徴とする
ストレス耐性付与方法。
[請求項6]
請求項5に記載のストレス耐性付与方法において、
前記導入工程が、注射投与、経口投与、及び噴霧投与から成る群より選択される投与により導入されることを特徴とする
ストレス耐性付与方法。
[請求項7]
請求項1~請求項4のいずれかに記載のストレス耐性付与組成物として昆虫類中のN-アセチルチロシン化合物及び/又はその誘導体を、前記昆虫類の体内で増加させて、ストレス耐性を増殖させるストレス耐性体内増殖方法であって、
前記昆虫類にストレスを付加するストレス付加工程を含むことを特徴とする
ストレス耐性体内増殖方法。
[請求項8]
請求項1~請求項4のいずれかに記載のストレス耐性付与組成物の含有量として前記昆虫類中のN-アセチルチロシン化合物及び/又はその誘導体の含有量を測定する測定工程と、
前記含有量に基づいて、前記昆虫類が受けているストレスの度合いを評価する評価工程を含むことを特徴とする
ストレス評価方法。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • SAGA UNIVERSITY
  • Inventor
  • HAYAKAWA Yoichi
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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