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SCHWANN CELLS AND METHOD FOR PREPARING SAME

Foreign code F160008784
File No. (S2014-1319-N0)
Posted date Aug 4, 2016
Country WIPO
International application number 2015JP075921
International publication number WO 2016039462
Date of international filing Sep 11, 2015
Date of international publication Mar 17, 2016
Priority data
  • P2014-186210 (Sep 12, 2014) JP
Title SCHWANN CELLS AND METHOD FOR PREPARING SAME
Abstract The present invention addresses the problem of providing a method for obtaining Schwann cells directly (by direct reprogramming) without going via pluripotent stem cells such as ES cells, iPS cells or the like. As a means for solving this problem, the present invention provides a method for preparing Schwann cells that includes a step of introducing, into somatic cells of a mammal, at least one type of gene selected from the group consisting of SOX10 genes and KROX20 genes, or an expression product of said gene.
Scope of claims [claim1]
1.  In mammalian somatic cells, comprising at least one gene or introducing an expression product thereof selected from the group consisting of SOX10 gene and KROX20 gene, a method of preparing Schwann cells.
[2]
[claim2]
2.  The gene is a combination of SOX10 gene and KROX20 gene, A method according to claim 1.
[3]
[claim3]
3.  The somatic cells are fibroblasts, endothelial cells or mesenchymal stem cells, the method according to claim 1 or 2.
[4]
[claim4]
4.  Derived from a mammalian somatic cells, at least one gene or Schwann cells with the expression product selected from the group consisting of SOX10 gene and KROX20 gene foreign.
[5]
[claim5]
5.  Treatment cells obtained by the method according to any one of claims 1-3, or comprises a Schwann cell according to claim 4, neurological defects, or defect in Schwann cells, diseases based on lack or reduced function for, graft material.
[6]
[claim6]
6.  SOX10 gene and comprises at least one gene or its expression product is selected from the group consisting of KROX20 genes, compositions for the preparation of Schwann cells.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KYOTO PREFECTURAL PUBLIC UNIVERSITY
  • Inventor
  • SOWA YOSHIHIRO
  • KISHIDA TSUNAO
  • MAZDA OSAM
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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