SCHWANN CELLS AND METHOD FOR PREPARING SAME
|Posted date||Aug 4, 2016|
|International application number||2015JP075921|
|International publication number||WO 2016039462|
|Date of international filing||Sep 11, 2015|
|Date of international publication||Mar 17, 2016|
|Title||SCHWANN CELLS AND METHOD FOR PREPARING SAME|
|Abstract||The present invention addresses the problem of providing a method for obtaining Schwann cells directly (by direct reprogramming) without going via pluripotent stem cells such as ES cells, iPS cells or the like. As a means for solving this problem, the present invention provides a method for preparing Schwann cells that includes a step of introducing, into somatic cells of a mammal, at least one type of gene selected from the group consisting of SOX10 genes and KROX20 genes, or an expression product of said gene.|
|Scope of claims||
1. In mammalian somatic cells, comprising at least one gene or introducing an expression product thereof selected from the group consisting of SOX10 gene and KROX20 gene, a method of preparing Schwann cells.
2. The gene is a combination of SOX10 gene and KROX20 gene, A method according to claim 1.
3. The somatic cells are fibroblasts, endothelial cells or mesenchymal stem cells, the method according to claim 1 or 2.
4. Derived from a mammalian somatic cells, at least one gene or Schwann cells with the expression product selected from the group consisting of SOX10 gene and KROX20 gene foreign.
5. Treatment cells obtained by the method according to any one of claims 1-3, or comprises a Schwann cell according to claim 4, neurological defects, or defect in Schwann cells, diseases based on lack or reduced function for, graft material.
6. SOX10 gene and comprises at least one gene or its expression product is selected from the group consisting of KROX20 genes, compositions for the preparation of Schwann cells.
|IPC(International Patent Classification)||
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
Contact Information for " SCHWANN CELLS AND METHOD FOR PREPARING SAME "
- Kyoto Prefectural University of Medicine Research suport office
- URL: https://www.kpu-m.ac.jp/doc/index.html
- Address: 465,Kajiicho,Kawaramachido-ri hirokouji,Kamigyo-ku,Kyoyo,Japan , 602-8566
- Phone: 81-75-251-5208
- Fax: 81-75-211-7093