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IMPLANT MATERIAL FOR NERVE REGENERATION, METHOD FOR MANUFACTURING IMPLANT MATERIAL FOR NERVE REGENERATION, AND KIT FOR MANUFACTURING IMPLANT MATERIAL FOR NERVE REGENERATION

外国特許コード F160008819
整理番号 (S2015-0038-N0)
掲載日 2016年8月9日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2015JP079334
国際公開番号 WO 2016060252
国際出願日 平成27年10月16日(2015.10.16)
国際公開日 平成28年4月21日(2016.4.21)
優先権データ
  • 特願2014-212085 (2014.10.16) JP
発明の名称 (英語) IMPLANT MATERIAL FOR NERVE REGENERATION, METHOD FOR MANUFACTURING IMPLANT MATERIAL FOR NERVE REGENERATION, AND KIT FOR MANUFACTURING IMPLANT MATERIAL FOR NERVE REGENERATION
発明の概要(英語) 1) An implant material for nerve regeneration characterized by comprising a collagen base material which contains a collagen having orientation properties. 2) A method for manufacturing an implant material for nerve regeneration, said method comprising a step for immersing a collagen base material containing a collagen having orientation properties in a solution containing a collagen binding site-containing growth factor, which contains a receptor agonist peptide moiety and a collagen binding peptide moiety, to thereby bind the collagen binding site-containing growth factor to the collagen. 3) A kit for manufacturing an implant material for nerve regeneration, said kit being characterized by comprising a collagen base material containing a collagen having orientation properties and a collagen binding site-containing growth factor which contains a receptor agonist peptide moiety and a collagen binding peptide moiety.
従来技術、競合技術の概要(英語) BACKGROUND ART
Nerve damage caused by trauma or tumor resection with respect to traffic, healthy nerve tissue transplantation of autologous nerve graft is being performed. However, the donor can be used as a limit on the length and diameter of the nerve tissue to be damaged or a donor extraction site in question. In recent years, the biological material is a prosthetic nerve have been developed, sufficient results are not obtained. On the other hand, to facilitate the self-repair of nerve damage in the prior art attempts have been made. To Patent Document 1, collagen is used as a scaffold for nerve regeneration of the nerve regeneration-inducing tube is disclosed. Patent Document 2 and 3 compiled from a biodegradable polymer fiber is a tubular body that the collagen coating, such as filling with the nerve regeneration-inducing tube is made is disclosed.
In recent years, can be used as the graft material, collagen orientation has been developed (Patent Document 4 and Patent Document 5). In Patent Document 5, a biocompatible material of collagen to have an orientation as a use to, osteoblasts or mesenchymal stem cells by seeding, substantially coincide with the direction of the orientation of collagen and apatite is oriented, and/or generated within the surface of the collagen, collagen/apatite to fix the orientation of the disclosed method of manufacture of the material. This is, the bone tissue of a biocompatible material having characteristics similar to those provided. Neuronal loss results in severe impairment with the passage of time, significantly decreases the quality of life of patients in addition to, the patient's social long-term treatment is delayed, directly in higher medical costs. Thus, for example, the recovery of the nerve damage at an early development of techniques that can be required.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • SCHOOL JURIDICAL PERSON KITASATO INSTITUTE
  • ATREE, INC.
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
  • NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
  • NIPPI, INCORPORATED
  • 発明者(英語)
  • UCHIDA Kentaro
  • INOUE Gen
  • FUJIMAKI Hisako
  • TAKASO Masashi
  • SAKU Taro
  • ISOBE Yoshihiro
  • MATSUSHITA Osamu
  • MIMA Takehiko
  • NISHI Nozomu
  • HATTORI Shunji
  • TANAKA Keisuke
  • OGURA Takayuki
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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