Top > Search of International Patents > IMPLANT MATERIAL FOR NERVE REGENERATION, METHOD FOR MANUFACTURING IMPLANT MATERIAL FOR NERVE REGENERATION, AND KIT FOR MANUFACTURING IMPLANT MATERIAL FOR NERVE REGENERATION

IMPLANT MATERIAL FOR NERVE REGENERATION, METHOD FOR MANUFACTURING IMPLANT MATERIAL FOR NERVE REGENERATION, AND KIT FOR MANUFACTURING IMPLANT MATERIAL FOR NERVE REGENERATION

Foreign code F160008819
File No. (S2015-0038-N0)
Posted date Aug 9, 2016
Country WIPO
International application number 2015JP079334
International publication number WO 2016060252
Date of international filing Oct 16, 2015
Date of international publication Apr 21, 2016
Priority data
  • P2014-212085 (Oct 16, 2014) JP
Title IMPLANT MATERIAL FOR NERVE REGENERATION, METHOD FOR MANUFACTURING IMPLANT MATERIAL FOR NERVE REGENERATION, AND KIT FOR MANUFACTURING IMPLANT MATERIAL FOR NERVE REGENERATION
Abstract 1) An implant material for nerve regeneration characterized by comprising a collagen base material which contains a collagen having orientation properties. 2) A method for manufacturing an implant material for nerve regeneration, said method comprising a step for immersing a collagen base material containing a collagen having orientation properties in a solution containing a collagen binding site-containing growth factor, which contains a receptor agonist peptide moiety and a collagen binding peptide moiety, to thereby bind the collagen binding site-containing growth factor to the collagen. 3) A kit for manufacturing an implant material for nerve regeneration, said kit being characterized by comprising a collagen base material containing a collagen having orientation properties and a collagen binding site-containing growth factor which contains a receptor agonist peptide moiety and a collagen binding peptide moiety.
Outline of related art and contending technology BACKGROUND ART
Nerve damage caused by trauma or tumor resection with respect to traffic, healthy nerve tissue transplantation of autologous nerve graft is being performed. However, the donor can be used as a limit on the length and diameter of the nerve tissue to be damaged or a donor extraction site in question. In recent years, the biological material is a prosthetic nerve have been developed, sufficient results are not obtained. On the other hand, to facilitate the self-repair of nerve damage in the prior art attempts have been made. To Patent Document 1, collagen is used as a scaffold for nerve regeneration of the nerve regeneration-inducing tube is disclosed. Patent Document 2 and 3 compiled from a biodegradable polymer fiber is a tubular body that the collagen coating, such as filling with the nerve regeneration-inducing tube is made is disclosed.
In recent years, can be used as the graft material, collagen orientation has been developed (Patent Document 4 and Patent Document 5). In Patent Document 5, a biocompatible material of collagen to have an orientation as a use to, osteoblasts or mesenchymal stem cells by seeding, substantially coincide with the direction of the orientation of collagen and apatite is oriented, and/or generated within the surface of the collagen, collagen/apatite to fix the orientation of the disclosed method of manufacture of the material. This is, the bone tissue of a biocompatible material having characteristics similar to those provided. Neuronal loss results in severe impairment with the passage of time, significantly decreases the quality of life of patients in addition to, the patient's social long-term treatment is delayed, directly in higher medical costs. Thus, for example, the recovery of the nerve damage at an early development of techniques that can be required.
Scope of claims (In Japanese)[請求項1]
配向性を有するコラーゲンを含むコラーゲン基材を具備する神経再生用移植材料。
[請求項2]
前記コラーゲンに、受容体アゴニストペプチド部とコラーゲン結合性ペプチド部とを含むコラーゲン結合部位含有成長因子が結合してなる請求項1に記載の神経再生用移植材料。
[請求項3]
中空の筒体形状を有し、該筒体の内面の少なくとも一部が前記コラーゲン基材により構成された請求項1又は2に記載の神経再生用移植材料。
[請求項4]
前記コラーゲンが、前記筒体の両端の開口部を結ぶ方向に配向性を有する請求項3に記載の神経再生用移植材料。
[請求項5]
前記コラーゲン結合部位含有成長因子は、前記成長因子受容体アゴニストペプチド部とコラーゲン結合性ペプチド部とがリンカー部を介して結合されたものであり、
前記リンカー部が、コラゲナーゼの多発性嚢胞腎Iドメインである請求項2~4のいずれか一項に記載の神経再生用移植材料。
[請求項6]
前記成長因子受容体アゴニストペプチド部は、塩基性線維芽細胞増殖因子である、請求項2~5のいずれか一項に記載の神経再生用移植材料。
[請求項7]
前記コラーゲン基材は、複数のコラーゲン基材層からなる請求項1~6のいずれか一項に記載の神経再生用移植材料。
[請求項8]
前記コラーゲン基材の厚みが、50μm以上、200μm以下である請求項1~7のいずれか一項に記載の神経再生用移植材料。
[請求項9]
配向性を有するコラーゲンを含むコラーゲン基材を、受容体アゴニストペプチド部とコラーゲン結合性ペプチド部とを含むコラーゲン結合部位含有成長因子を含有する溶液に浸漬させて、前記コラーゲンに前記コラーゲン結合部位含有成長因子を結合させる工程を有する神経再生用移植材料の製造方法。
[請求項10]
配向性を有するコラーゲンを含むコラーゲン基材、
及び受容体アゴニストペプチド部とコラーゲン結合性ペプチド部とを含むコラーゲン結合部位含有成長因子、
を備えた神経再生用移植材料製造用キット。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • SCHOOL JURIDICAL PERSON KITASATO INSTITUTE
  • ATREE, INC.
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
  • NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
  • NIPPI, INCORPORATED
  • Inventor
  • UCHIDA Kentaro
  • INOUE Gen
  • FUJIMAKI Hisako
  • TAKASO Masashi
  • SAKU Taro
  • ISOBE Yoshihiro
  • MATSUSHITA Osamu
  • MIMA Takehiko
  • NISHI Nozomu
  • HATTORI Shunji
  • TANAKA Keisuke
  • OGURA Takayuki
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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