Top > Search of International Patents > MEDICINAL COMPOSITION FOR TREATING AND/OR PREVENTING ESOPHAGEAL STENOSIS

MEDICINAL COMPOSITION FOR TREATING AND/OR PREVENTING ESOPHAGEAL STENOSIS

Foreign code F160008846
File No. S2014-1359-C0
Posted date Sep 14, 2016
Country WIPO
International application number 2015JP072385
International publication number WO 2016024524
Date of international filing Aug 6, 2015
Date of international publication Feb 18, 2016
Priority data
  • P2014-164429 (Aug 12, 2014) JP
Title MEDICINAL COMPOSITION FOR TREATING AND/OR PREVENTING ESOPHAGEAL STENOSIS
Abstract Provided is a medicinal composition for treating and/or preventing esophageal stenosis that comprises an HGF protein as an active ingredient, wherein said HGF protein is one of the following polypeptides: (a) a polypeptide comprising an amino acid sequence represented by SEQ ID NO:2; (b) a polypeptide comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO:2 by deletion, substitution or addition of one to several amino acids; and (c) a polypeptide comprising an amino acid sequence having a 90% or more identity with the amino acid sequence represented by SEQ ID NO:2. Also provided is a stent that comprises the medicinal composition.
Outline of related art and contending technology BACKGROUND ART
In the esophagus, esophageal cancer at an early stage (superficial esophageal cancer) with respect to the endoscopic submucosal layer peeling is generated at a high rate after surgery is constricted. Post-operative release submucosa such endoscopic esophageal stricture for balloon dilatation is used, difficulty in swallowing such as stenosis of a plurality of times the symptoms require dilatation, can easily be obtained once expanded also often relapse.
As described above with respect to the esophageal stricture of post-surgical release the submucosal layer, other than the endoscopic balloon dilatation effective solution is not known until now.
On the other hand, HGF is, in the year 1986 goda tsubouchi et al. fulminant hepatitis and isolated from the patient's plasma, a growth factor that promotes lung and reproduction (non-patent document 1), the human cDNA is, cloned in the year 1989 (non-patent document 2). Various stem cells as well as HGF epithelial system cells, endothelial cells and some mesenchymal cells such as with a variety of cell proliferation to exert their effect. In addition, alimentary canal mucosa injury HGF factor essential in the repair, repair of mucosal injury-promoting effects, experiments with recombinant human HGF enteritis model has been confirmed (non-patent document 3-5).
However, effective against HGF is intestinal tract stenosis, not known until now.
Scope of claims (In Japanese)[請求項1]
肝細胞増殖因子(HGF)タンパク質を有効成分として含有する、食道狭窄を治療及び/又は予防するための医薬組成物。
[請求項2]
食道狭窄が、内視鏡的粘膜下層剥離術後の食道狭窄である、請求項1に記載の医薬組成物。
[請求項3]
HGFタンパク質が、ヒトHGFタンパク質である、請求項1又は2に記載の医薬組成物。
[請求項4]
HGFタンパク質が、組み換えHGFタンパク質である、請求項1~3のいずれか1項に記載の医薬組成物。
[請求項5]
HGFタンパク質が、
(a)配列番号2で示されるアミノ酸配列を含むポリペプチド、
(b)配列番号2で示されるアミノ酸配列において、1若しくは数個のアミノ酸が欠失、置換若しくは付加されたアミノ酸配列を含むポリペプチド、又は
(c)配列番号2で示されるアミノ酸配列と90%以上の同一性を有するアミノ酸配列を含むポリペプチド、
のいずれかのポリペプチドである、請求項1~4のいずれか1項に記載の医薬組成物。
[請求項6]
食道狭窄が食道潰瘍に起因する、請求項1~5のいずれか1項に記載の医薬組成物。
[請求項7]
食道潰瘍が修復される、請求項1~6のいずれか1項に記載の医薬組成物。
[請求項8]
請求項1~7のいずれか1項に記載の医薬組成物を含むステント。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KAGOSHIMA UNIVERSITY
  • Inventor
  • IDO Akio
  • TSUBOUCHI Hirohito
  • KOMAKI Yuga
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
Please contact us by E-mail if you have any interests on this patent.

PAGE TOP

close
close
close
close
close
close