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METHOD AND KIT FOR DETECTING KAWASAKI DISEASE

外国特許コード F160008851
整理番号 (S2015-0453-N0)
掲載日 2016年9月23日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP053940
国際公開番号 WO 2016129631
国際出願日 平成28年2月10日(2016.2.10)
国際公開日 平成28年8月18日(2016.8.18)
優先権データ
  • 特願2015-024506 (2015.2.10) JP
発明の名称 (英語) METHOD AND KIT FOR DETECTING KAWASAKI DISEASE
発明の概要(英語) A method and kit for quickly and simply detecting Kawasaki disease is provided. The method for detecting Kawasaki disease comprises measuring the level of at least one component selected from the group consisting of a lipopolysaccharide-binding protein, leucine-rich α2-glycoprotein, angiotensinogen and retinol-binding protein 4 in a sample originating from a subject. The kit for detecting Kawasaki disease comprises at least one reagent selected from a group consisting of a reagent capable of specifically detecting the lipopolysaccharide-binding protein, a reagent capable of specifically detecting leucine-rich α2-glycoprotein, a reagent capable of specifically detecting angiotensinogen and a reagent capable of specifically detecting retinol-binding protein 4.
従来技術、競合技術の概要(英語) BACKGROUND ART
Kawasaki disease 4 years of age or less is mainly found in infant acute febrile rash and disease, systemic vasculitis in a subject of the disease. Kawasaki disease symptoms of the plurality of primary diagnosis (1.5 for more than the heat generation, 2. on both sides of the ocular hyperemia of the conjunctiva, 3. and the lip redness, concentrate the tongue, 4. of the irregular shaped rash, 5. acute phase of the hand fingers of the rigid, palmar and plantar erythema, antipyretic of the film-like desquamation, the neck 6. of the non-suppurative lymphadenopathy) made by the appearance of (kawasaki disease diagnosis guidance). In the blood, white blood cell count, C-reactive protein, an enzyme without departing from the increase of the liver cells, an increased erythrocyte sedimentation, fractions such as leukocytes (neutrophil ratio) is checked, two-dimensional echocardiography or cardiovascular angiography of the coronary artery lesions such as a check is also performed.
Kawasaki disease is a disease which is a natural sophisticated, when passing the non-treated patients with coronary lesions 25-30% cardiac complications typically occur. Therefore, kawasaki disease onset of the treatment was initiated, it is important that soothe inflammation, and to reduce the period of heat that even 1, it is possible to prevent the occurrence of complications of the heart is necessary. However, kawasaki disease pathogenesis is still unknown and for the development mechanism and, instead of the specific diagnostic tests, and also the individual difference of the major symptoms, there are a multitude of example does not meet the diagnostic criteria. Therefore, it is difficult for the rapid kawasaki disease a definite diagnosis.
In addition, the diagnosis of kawasaki disease patents, the blood in the VEGF (vascular endothelial growth factor: vascular endothelial growth factor) a method of measuring the concentration (Patent Document 1: JP-11-6832), IgM or 1 a method of measuring a plurality of super antigen (Patent Document 2: JP-3-139294), otherwise, the investigation of genetic polymorphism (Patent Document 3: JP-2009-72193) and the like, the actual clinical field is not yet been effectively utilized.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY
  • 発明者(英語)
  • HORIUCHI YAYOI
  • MORI MASAAKI
  • HIRANO HISASHI
  • YOKOTA SHUMPEI
  • SAITO YOKO
  • AKETAGAWA MAO
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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