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ANTITUMOR AGENT

外国特許コード F160008856
整理番号 (S2015-0491-N0)
掲載日 2016年9月23日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP053960
国際公開番号 WO 2016129633
国際出願日 平成28年2月10日(2016.2.10)
国際公開日 平成28年8月18日(2016.8.18)
優先権データ
  • 特願2015-024713 (2015.2.10) JP
発明の名称 (英語) ANTITUMOR AGENT
発明の概要(英語) The present invention provides a composition and method for treatment or prevention in a subject having a tumor (e.g., a brain tumor, breast cancer, colon cancer, prostate cancer, liver cancer, lung cancer, leukemia, lymphoma, or the like) in which the TUG1 gene is expressed at a high level relative to normal tissue, the composition including as an active ingredient a nucleic acid for suppressing high-level expression of the TUG1 gene in tumor stem cells.
従来技術、競合技術の概要(英語) BACKGROUND ART
TUG1 Is, and the abbreviation of taurine upregulated gene 1, differentiation of the retina of rodents as necessary the noncoding RNA such as Young et al. (non-patent document 1) has been identified by RNA splicing and polyadenylation, retina and brain tissue of the nervous system such as a strong expression.
The role of TUG1 in the cancer or tumor, for example non-small cell lung (NSCLC) to knock-down TUG1 and cell growth is promoted by Zhang et al. (non-patent document 2) have been described. On the other hand, in a particular cancer or tumor is over-expressed and TUG1, and suppresses the expression of TUG1, a report that proliferation is inhibited. For example, the (non-patent document 3) Xu et al., TUG1 esophageal squamous cell carcinoma (ESCC) by silencing of suppressed the growth of cells and inhibition of cell cycle progression have been described above. In addition, Zhang et al. (non-patent document 4) is, in the osteosarcoma cell line which is over-expressed TUG1, in addition, inhibits the expression of the TUG1 osteosarcoma cell and cause apoptosis is described. Furthermore, Han et al. (non-patent document 5) is, TUG1 urothelial cancer is over-expressed, high stage disease and, in addition, silences TUG1 takes place in the growth inhibition or apoptosis induction and described.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY
  • 発明者(英語)
  • KONDO YUTAKA
  • KATSUSHIMA KEISUKE
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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