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PEPTIDES HAVING AFFINITY FOR POLYDIMETHYLSILOXANE, AND USES THEREOF UPDATE

外国特許コード F160008859
整理番号 (S2015-0636-N0)
掲載日 2016年9月23日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP054195
国際公開番号 WO 2016129695
国際出願日 平成28年2月12日(2016.2.12)
国際公開日 平成28年8月18日(2016.8.18)
優先権データ
  • 特願2015-026489 (2015.2.13) JP
発明の名称 (英語) PEPTIDES HAVING AFFINITY FOR POLYDIMETHYLSILOXANE, AND USES THEREOF UPDATE
発明の概要(英語) The purpose of the present invention is to provide: a polydimethylsiloxane substrate obtained through the bonding of peptides having an affinity for polydimethylsiloxane (PDMS); a method for immobilizing a target protein on the polydimethylsiloxane substrate; peptides having an affinity for PDMS; polynucleotides for coding the peptides having an affinity for PDMS; and vectors and the like that use the polynucleotides. A polydimethylsiloxane substrate obtained through the bonding of peptides having an affinity for polydimethylsiloxane, said peptides comprising (1a) or (1b) below or fragments thereof. (1a) A peptide comprising an amino acid sequence represented by at least one sequence selected from the group consisting of SEQ ID Nos. 1 to 9. (1b) A peptide having an affinity for polydimethylsiloxane, and comprising an amino acid sequence in which one or a plurality of amino acids have been deleted, substituted and/or added in the amino acid sequence of (1a).
従来技術、競合技術の概要(英語) BACKGROUND ART
Conventional, clinical testing, drug discovery, environmental monitoring, in various fields including biochemistry, protein, nucleic acid, is fixed to the substrate cells and the like, of the desired material using this detection, quantitation, analysis and the like are widely used method. As an example, an enzyme or an antibody fixed to the protein-based, enzymatic reactions with the immobilized protein or an antigen-antibody reaction of a method for detecting of the desired material has been known.
In such a method, a higher degree of accuracy and high detection, quantitation, analysis and the like to gain access to the studied actively today have been carried out, for example according to the purpose of the surface of the substrate or plasma is performed on the chemical treatment have been reported. Also, for example a polystyrene substrate (patent document 1) can be immobilized protein or peptide, a polycarbonate substrate or base material made of polymethyl methacrylate can be firmly fixed to a specific protein and peptide have been reported (patent document 2).
On the other hand, a type 1 polydimethylsiloxane made of silicone rubber, it can be finely processed, typified by the microfluidic channel of the microchip is known as one of the substrate. Preferably polydimethylsiloxane by fixing the protein of the desired material can be detected with high accuracy and high efficiency and the like, a base made of polydimethylsiloxane a further development of the method to use can be expected. However, this affinity for the base material made of polydimethylsiloxane to the peptide is not known.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY
  • NISSAN CHEMICAL INDUSTRIES, LTD.
  • 発明者(英語)
  • KUMADA YOICHI
  • OTSUKI RYOKO
  • AKAI RYOTA
  • KATAYAMA JUNKO
  • MATOBA KAZUTAKA
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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