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PRODUCTION METHOD FOR OPTICALLY ACTIVE COMPOUND, AND TRIAZOLIUM SALT USED AS CATALYST IN SAME UPDATE コモンズ

外国特許コード F160008893
整理番号 NU-663
掲載日 2016年10月27日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP069888
国際公開番号 WO 2017006929
国際出願日 平成28年7月5日(2016.7.5)
国際公開日 平成29年1月12日(2017.1.12)
優先権データ
  • 特願2015-135120 (2015.7.6) JP
発明の名称 (英語) PRODUCTION METHOD FOR OPTICALLY ACTIVE COMPOUND, AND TRIAZOLIUM SALT USED AS CATALYST IN SAME UPDATE コモンズ
発明の概要(英語) The present invention makes it easy to obtain, with good yield and stereoselectivity, an optically active α-tetrasubstituted α-amino nitrile derivative, or an intermediate for the synthesis of said derivative, by reacting a cyanometalate with a compound represented by formula (3), in which R1-R3 are as described, under the presence of a triazolium salt represented by formula (2), in which R5 and R8-R10 are the same or different and represent an aryl group which may be substituted, R6 represents a primary alkyl group which may be substituted, R7 represents a fatty alkyl group which may be substituted, or a cycloalkyl group which may be substituted, and X1 represents a halogen atom or a monovalent anion.
従来技術、競合技術の概要(英語) BACKGROUND ART
Aminonitrile derivatives and optically active α tetrasubstituted α α tetrasubstituted α amino acids are optically active, are intermediates for synthesis of surgeon pesticide product widely used. Aminonitrile derivatives and optically active α α α tetra - substituted tetra-substituted α amino acids as the synthesis method, for example, using the cyanation reaction (strand reaction) and a step of the method used is known. However, have low reactivity, in addition, cyanation reaction (strand reaction) it is difficult to control the stereochemistry at the and of a catalyst, yield and steric selectivity can be difficult to synthesize. Such an aminonitrile derivatives and optically active α α α tetra - substituted tetra-substituted α amino acids as the synthesis method, optically active presence of a catalyst, the reaction to proceed using hydrogen cyanide or method used was a step also known (for example, such as non-patent document 1-2). However, difficult to handle the hydrogen cyanide and high volatility, is relatively costly .
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
  • 発明者(英語)
  • OOI TAKASHI
  • OHMATSU KOHSUKE
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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