TOP > 外国特許検索 > MARKER FOR UNDIFFERENTIATED MESENCHYMAL STEM CELLS AND USE THEREOF

MARKER FOR UNDIFFERENTIATED MESENCHYMAL STEM CELLS AND USE THEREOF コモンズ

外国特許コード F160008911
整理番号 NU-668
掲載日 2016年12月1日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP071190
国際公開番号 WO 2017022472
国際出願日 平成28年7月19日(2016.7.19)
国際公開日 平成29年2月9日(2017.2.9)
優先権データ
  • 特願2015-153712 (2015.8.3) JP
発明の名称 (英語) MARKER FOR UNDIFFERENTIATED MESENCHYMAL STEM CELLS AND USE THEREOF コモンズ
発明の概要(英語) The present invention addresses the problem of providing a marker molecule that is highly specific for mesenchymal stem cells in an undifferentiated state and enables identification of mesenchymal stem cells at a high sensitivity or preparation of highly pure mesenchymal stem cells. Provided are a marker for undifferentiated mesenchymal stem cells, said marker comprising immunoglobulin superfamily containing leucine-rich repeat, and a use of the same.
従来技術、競合技術の概要(英語) BACKGROUND ART
Mesenchymal stem cells or mesenchymal stromal cell (mesenchymal stem cell. Or less, may be abbreviated as' MSC ') bone marrow, adipose tissue, tooth pulp, umbilical cord, as well as the endometrium and cells present in many organs, culture dishes are cultured under conditions to the above-identified bone, cartilage and fat differentiation are known. In addition, a group of cells of mesenchymal stem cells being operative for facilitating proliferation and differentiation of the immunomodulatory ability (trophic effect) and also known to have, at present GVHD (graft versus host disease), spinal cord injuries, kidney failure after kidney transplantation, myocardial infarction, such as peripheral occlusive arterial disease of the various diseases are expected to be applied to the treatment.
Mesenchymal stem cells are bone marrow and sinusoidal blood vessels such as the facial artery, around the capillaries in other organs known to be present in the (non-patent document 1). Bone marrow cells from the niche for maintaining hematopoietic stem cells, bone cells for regeneration of the functions as the metaphysis (non-patent document 2). In the organs other than bone marrow or peri site around blood vessels (vascular pericytes) as cells and fibroblasts, and maturation of blood vessels is related to the (non-patent document 3). In addition, cancer and various fibrosis in diseases leading to interstitial fibrosis and proliferation of the peri site (non-patent document 4) theories may also be present.
Satisfy the following conditions (1) - (3) international cells and mesenchymal stem cells are defined. (1) Is a cell culture dish CD105 the adhesive can (2) be positive, CD73 positive, CD90 positive, CD45 negative, CD34 negative, CD14 negative or CD11b, CD19 or CD79a negative, HLA-DR(in vitro) to be negative (3) in the test tube in osteoblasts, chondrocytes and differentiation of preadipocytes into adipocytes can be used together
In addition to the above-listed (2) molecules, Stro-1, PDGF receptor, Sca-1, CD271, CD146 mesenchymal stem cells and the like have been reported as a marker of, combinations of these markers in methods for isolating mesenchymal stem cells that have been developed (see for example Patent Document 1). However, the above-described CD105, CD73, CD90 including, epithelial cells or any cancer cell markers, such as neural cells or to express, mesenchymal stem cells are not specific.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
  • 発明者(英語)
  • ENOMOTO Atsushi
  • TAKAHASHI Masahide
  • MAEDA Keiko
  • HARA Akitoshi
  • MIZUTANI Yasuyuki
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
名古屋大学の公開特許情報を掲載しています。ご関心のある案件がございましたら、下記まで電子メールでご連絡ください。

PAGE TOP

close
close
close
close
close
close