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MEMORY-IMPROVING AGENT AND USE THEREOF

外国特許コード F170008917
整理番号 (S2015-0748-N0)
掲載日 2017年1月13日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP062006
国際公開番号 WO 2016167318
国際出願日 平成28年4月14日(2016.4.14)
国際公開日 平成28年10月20日(2016.10.20)
優先権データ
  • 特願2015-084402 (2015.4.16) JP
発明の名称 (英語) MEMORY-IMPROVING AGENT AND USE THEREOF
発明の概要(英語) Provided are: a memory-improving agent and memory-improving composition containing as an active ingredient a compound that is an inverse agonist of opioid δ receptors, a pharmacologically acceptable salt thereof, or a solvate of these; and a compound represented by formula (5), a pharmacologically acceptable salt thereof, or a solvate of these.
従来技術、競合技術の概要(英語) BACKGROUND ART
Opioid receptor, the action of morphine-like substances (opioid) involved in expression of cell surface receptor proteins and, at least, μ (hereinafter, 'opioid μ receptor' is referred.), Κ (hereinafter, 'opioid κ receptor' is referred.), Δ (hereinafter, 'opioid δ receptor' is referred.) Of the known subtypes of 3.
Of the thalamus and cerebral cortex stimulation of opioid μ receptor, the activation of the descending suppressive system, exhibit analgesic effect indirectly. In addition, the opioid μ receptor present in the spinal cord dorsal horn upon stimulation, directly inhibit the transmission of the noxious stimulus, exhibit analgesic effect. Opioid μ receptors include, other than these, reduced gastrointestinal movement, miosis, euphoria feeling, bradycardia, neurotransmitters such as suppressing effects on has been known.
Κ opioid receptors, the hypothalamus, and are present in the spinal cord, spinal opioid κ receptor activated, pain relief or sedation, miosis, bradycardia known to occur.
The channel system opioid δ receptor is present more on the extrapyramidal, emotion, control of the neurotransmitter, been implicated depends on, and is considered to be a weak analgesic effect. Δ opioid receptor ligands include, naruto le indole (NTI), narutoriben (NTB), 7 - (BNTX) benzylidene naltrexone and the like are known (for example, see non-patent document 1-3).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • SCHOOL JURIDICAL PERSON KITASATO INSTITUTE
  • 発明者(英語)
  • FUJII Hideaki
  • HIRAYAMA Shigeto
  • TANABE Mitsuo
  • IWAI Takashi
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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