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EVALUATION OF INHIBITORY CIRCUIT AND USE THEREOF UPDATE

外国特許コード F170008950
整理番号 (S2015-1410-N0)
掲載日 2017年2月16日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP068144
国際公開番号 WO 2016204282
国際出願日 平成28年6月17日(2016.6.17)
国際公開日 平成28年12月22日(2016.12.22)
優先権データ
  • 特願2015-122657 (2015.6.18) JP
発明の名称 (英語) EVALUATION OF INHIBITORY CIRCUIT AND USE THEREOF UPDATE
発明の概要(英語) Provided are a more practical method of evaluating an inhibitory circuit applicable to a living body and the use thereof. Herein the action of an inhibitory circuit on an excitatory circuit is evaluated on the basis of attenuation of the brain activity produced by activation of an excitatory circuit by the input of an inhibitory circuit by performing a step for inputting an inhibitory circuit by applying a second trigger in advance of a first trigger to an excitatory circuit activated by a first trigger which is a stimulus or challenge.
従来技術、競合技術の概要(英語) BACKGROUND ART
E. g. in the brain and neural excitatory pyramidal neurons convey and interneurons suppress Mn. Inhibitory interneuron entity is the GABA (γ-aminobutyric acid, γ - amino butyric acid) is used as a neurotransmitter GABA neurons is well known, so too does the human thought. GABA is common practice in animal studies the brain neuronal activity using a sample slice electrophysiological pharmacologic observed.
GABA inhibitory interneuron the operability of the suppression circuit that some abnormality has been estimated in a number of diseases, epilepsy, essential tremor, schizophrenia, panic, overactive, mania, depression, autism or the like in the example. Elucidation of the function of suppressing circuitry, associated with abnormal brain inhibitory circuit elucidation of the pathophysiology of the disease as well as various types, such diseases of the development of therapeutics, in cases of individual inhibitory function of the circuit is extremely important to know the abnormality. In addition, the inhibitory function of the circuit in a normal range, to communicate excitement excitatory pyramidal neurons strongly suppressed by the circuit to determine the depth of the individual difference is whether the circuit works. The suppression circuit that varies from a person associated with the sensory properties for each individual is considered, provide products with a personalized industry in a case where an inhibitory interneuron a high significance to evaluate the inhibitory circuits.
The subject is in-circuit, the circuit is connected to the excitatory synaptic inhibitory interneuron from which the release of neurotransmitters, this action is connected in the nerve cells of the target from the post synaptic potentials (IPSP) can be observed directly record.
Such suppression circuit is evaluated, in general, using a sample slice of the brain or pharmacologically electrophysiological performed. In addition, in the living animal such as a human, the evaluation is not possible, instead of directly viewing the IPSP, excitatory activity as an index, which is generated in the observation method in which a suppression have been reported (Non-Patent Document 1). The method, the motor area of the magnetic stimulation to induce muscle activity and, prior to this stimulation feeble magnetic stimulation is applied, thereby reducing the phenomenon of the prior to stimulation by the muscle activity (pre-pulse, inhibition) is used. Then, subtracting the extent of inhibition from the muscle activity can be evaluated.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES
  • TOKAI OPTICAL CO., LTD.
  • 発明者(英語)
  • INUI Koji
  • TAKESHIMA Yasuyuki
  • SUZUKI Masaya
  • KUMAGAI Naoya
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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