CATECHOL-CONTAINING ADHESIVE HYDROGEL, COMPOSITION FOR PREPARING ADHESIVE HYDROGEL, AND COMPOSITIONS EACH INCLUDING SAID ADHESIVE HYDROGEL
|発明の名称 （英語）||CATECHOL-CONTAINING ADHESIVE HYDROGEL, COMPOSITION FOR PREPARING ADHESIVE HYDROGEL, AND COMPOSITIONS EACH INCLUDING SAID ADHESIVE HYDROGEL|
|発明の概要（英語）||A hydrogel which adheres to surfaces of materials is provided by using, as constituent elements, a water-soluble main-chain monomer, a crosslinking agent, a polymerization initiator, and an adhesive monomer having at least a catechol group in a side chain.|
Cross-linked polymer hydrogel is formed three-dimensional network structure body 3. The hydrogel have water absorptivity, is flexible, absorbent which is rich in, the system can be a phase transition in which the medical materials, industrial products, used in various fields. For example, as medical materials, tissue adhesive wound-healing material, adhesion of the implant, such as the matrix for the drug delivery system (DDS), has been studied in various applications.
In recent years, a variety of functions depending upon the purpose thereof is applied to the hydrogel, can be applied to a desired purpose has been studied. In addition, thermal, electrical, light, such as pH, that perceived the light stimulus from the outside is gel 'smart gel' functions autonomously performed has been actively developed. In this way, given a variety of functions have been developed but the hydrogel, the hydrogel is a metal or the like, and the adhesion thereof to the other material surface not provided with the most limited applications and is the cause.
The hydrogel to the surface of the other materials as the reason why the adhesion is provided, crosslinking of the hydrogel polymer 3 is supported on the three-dimensional network water and high moisture content can be, easily deformed structure are a major source. Therefore, the hydrogel imparting adhesive properties various attempts have been made. A substrate such as a phenyl azide group up to now photoinitiator groups are introduced may be fixed and a hydrogel, an excimer laser to destroy part of the gel after the disclosed is a method of attaching a (non-patent document 1, 2).
In addition, the chemical modification of the polymer main chain, an adhesive group is introduced into the disclosed method. Is Patent Document 1, dopa (3,4-dihydroxyphenylalanine, DOPA), or through binding tissue adhesion force Dopaston derivative of biocompatible tissue adhesive hydrogel injection type disclosed. Dopa derivatives, represented by a family of mussels mussels, exposed to a humid environment even in an environment of intense flushing, rock, wood, metal, concrete structures and the like, a variety of materials found to adhere to the surface from the adhesive material. Mussel is, included in the yarn from the glands secrete Dopaston foot catechol group even in water and a variety of materials can be firmly adhered to. Is Patent Document 1, the main chain of the hydrogel Dopaston derivatives by coupling a compound having, a hydro-gel was made the adhesion according to the present invention.
Is Patent Document 2, has a main chain and a chain-shaped side chain polyacrylate structure such as a polymer having the structure oligoalkylene oxide substrate by impregnating the porous film, a polymeric gel adhesive disclosed is a method.
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
|参考情報 （研究プロジェクト等）||PRESTO Molecular technology and creation of new functions AREA|
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