INJECTION NEEDLE SUPPORT FASTENER AND INJECTION NEEDLE IMPLEMENT
|発明の名称 （英語）||INJECTION NEEDLE SUPPORT FASTENER AND INJECTION NEEDLE IMPLEMENT|
|発明の概要（英語）||Provided is an injection needle implement with which a perfusion fluid can be easily and reliably injected into the heart of a test animal. Also provided is an injection needle support fastener 800 for supporting and fastening an injection needle during injection of a drug into tissue. The injection needle support fastener has an injection needle support part for exposing the needle tip of the injection needle and supporting the injection needle, and an injection needle fastening part for being attached to the tissue and thereby fastening the injection needle which has punctured tissue. The injection needle support part is equipped with a first plate part 220 and a second plate part 230, and adhesively supports the injection needle by sandwiching the needle between the first plate part 220 and the second plate part 230, with the tip of the needle being exposed therefrom.|
And the perfusion liquid is injected into the animal for an experiment when advancing the experimental protocol, the perfusion liquid is injected into the heart of the animal for an experiment to it. For example, in the fixation of the rats, rats were anesthetized with an anesthetic in the chest incision to be observed in the heart. For example the left hand of the injection needle instrument, the forceps hook has a free hand, the injection needle into the left ventricle than the apex of the heart, allowing the entry of the needle tip to the upper side. If the injection needle does not come off the needle and hook-free forceps is fixed to the heart. Phosphate buffered saline to flow, the perfusion solution and then fixed, when an animal becomes hard tissue was removed, the liquid storage and fixed (non-patent document 1, 2).
In the perfusion-fixation, the central nervous system is susceptible to rapid postmortem perfusion solution was injected for tissue fixation it is required to, in addition, particularly embryonic period immediately after birth or experimental animals such as in the case of small individuals, the injection needle puncturing the heart is small, such as fixation for these reasons that may not be appropriately performed. For example, by way of the needle into the left ventricle to the left ventricle at a location other than the erroneous puncturing needle, for example a syringe needle into the left atrium after puncturing, a hypodermic needle penetrates the injection needle tip is not located at appropriate locations in the ventricle after the puncture, the injection needle and for example it is not appropriate to fixing of the puncture needle through the injection needle being, is a problem.
Such a fixation failure while it is possible to reduce the number of training, cannot be completely avoided. Particularly for a novice to completely control these issues it is extremely difficult, the burden on the practitioner and the work of the laboratory animal is large. Also easily and accurately by a novice of the test animals and allowing perfusion of the heart is said that the significance of the very life science research.
Therefore, the degree of advance in the middle of the injection needle 45-60 in the position of the bending angle is a method. According to such approach, the injection needle of the mark and the bent portions, the entry into the heart to more easily know the length of the injection needle, since the inner wall of the injection needle by hooking the bent portions of the heart becomes easy to carry out the fixing of the injection needle. However, the injection needle is bent in a hypodermic needle may be damaged and, further, the injection needle in the bent portions and confines the flow path may not be injected into the perfusate may be appropriate. Further the injection needle is bent as the endocardial wall of the hooked portion, the degree of engagement is weak, a certain amount of force is applied can be considered to be out of the hypodermic needle.
On the other hand, in Patent Document 1, the needle body and needle position regulating member including an injection needle instrument is described. The needle body, the syringe needle, the needle position in contact with a stopper member for positioning, provided to the side surface of the injection needle oblique to the proximal end side and a return member projects. Position-defining member is a needle, through which the injection needle has a rubber member, the injection needle through the rubber member, the stopper positioning the regulating member to a predetermined position of the needle position when positioned in contact with, engaged with the return member is made of a rubber member.
Patent Document 1 of the present invention is to pierce the human skin is used for injecting a liquid and the injection needle instrument, the return member to prevent a shift of the injection needle by human skin more than necessary in order not to damage, the rubber member and engage with, the injection needle of Patent Document 1 as the instrument and the number of parts. In this way, human skin is an injection needle injecting a liquid, increasing the number of parts is safe for the information on the configuration is found, for example, the perfusion liquid is injected into the heart of the animal for an experiment in which an injection needle, the safety of the animal to be injected is not required, but rather are injected into the irrigating fluid can therefore be easily and reliably, perfusion of the animal for an experiment for increasing the number of the needle of the instrument to prevent such a request. In addition, the invention described in Patent Document 1 the position-defining member is fixed to the needle in the injection needle if it is intended to relatively large part, perfusion of the heart of the animal for an experiment as to the surgical site is difficult to be transferred is small. In addition, the invention described in Patent Document 1 such as the skin dryness and rich flatness and target sites, such as small animals and small wetted and precisely fixed to the curved surface is difficult to use.
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EAPO: AM AZ BY KG KZ RU TJ TM
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