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ANTI-HEPATITIS B VIRUS DRUG

外国特許コード F170009007
整理番号 (S2015-1715-N0)
掲載日 2017年3月29日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP069793
国際公開番号 WO 2017010330
国際出願日 平成28年7月4日(2016.7.4)
国際公開日 平成29年1月19日(2017.1.19)
優先権データ
  • 特願2015-138773 (2015.7.10) JP
発明の名称 (英語) ANTI-HEPATITIS B VIRUS DRUG
発明の概要(英語) Provided is a novel anti-hepatitis B virus (HBV) drug that has a different function mechanism (a target molecule) from existing medicines. The anti-HBV drug comprises a compound represented by formula (I), a tautomer thereof or a salt or solvate of the same [in formula (I), R1, R2 and R3 are the same or different and represent an optionally substituted C1-6 alkyl group or an optionally substituted aromatic group].
従来技術、競合技術の概要(英語) BACKGROUND ART
A hepatitis virus (HBV) chronic hepatitis B cirrhosis or the liver is one of the 1 leading cause of cancer. Current, (about 110 million) Japanese 0.9% is estimated to be HBV and carrier, about 3 million of the world and is considered to be the presence of a carrier. Prevention of infection is HBV vaccine have been developed, some anti-HBV drugs may also has been already present, lamivudine, adefovir, entecavir are on the market are the. And these are all nucleic acid analogs, having a function of the reverse transcription polymerase HBV DNA targets. By the use of these, HBV in blood is lost. However, the various forms of the stable within the cells in the liver HBV DNA exists as, discontinuation of the chemotherapy by an anti-viral agent, there is the risk of relapse of hepatitis. In addition, drug resistance to existing anti-HBV agent virus is also reported. For this reason, the existing mechanism of action of a drug different (target molecule), the development of new anti-HBV agents has been desired.
On the other hand, as the triazine derivatives -6 - pyrimido 1, 2-a1, 3, 5, many compounds have been reported (non-patent document 1 and non-patent document 2). However, triazine derivatives and anti-pyrimido 1, 2-a1, 3, 5 active HBV -6 - in terms of the relationship has never been hitherto been reported.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KAGOSHIMA UNIVERSITY
  • 発明者(英語)
  • BABA Masanori
  • TOYAMA Masaaki
  • SAKAKIBARA Norikazu
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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