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NOVEL COMPOUND THAT SPECIFICALLY BINDS TO AMPA RECEPTOR

外国特許コード F170009020
整理番号 (S2015-1685-N0)
掲載日 2017年3月29日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP069896
国際公開番号 WO 2017006931
国際出願日 平成28年7月5日(2016.7.5)
国際公開日 平成29年1月12日(2017.1.12)
優先権データ
  • 特願2015-135124 (2015.7.6) JP
発明の名称 (英語) NOVEL COMPOUND THAT SPECIFICALLY BINDS TO AMPA RECEPTOR
発明の概要(英語) The present invention provides a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. This compound is capable of specifically binding to an AMPA receptor, and shows extremely high brain uptake. (In the formula, each of A and Z independently represents CO, SO or SO2; each of X and Y independently represents S or O; each of R1-R4 independently represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group or a halogen group; each R5 independently represents an alkyl group, an alkenyl group, an alkynyl group or a halogen group; and n represents an integer of 0-4.)
従来技術、競合技術の概要(英語) BACKGROUND ART
AMPA receptors are widely distributed in the nervous system, learning, memory, neurodegenerative, or the like and cell death are known to be involved. In recent years, targeted receptor AMPA, spirit, for the treatment of neurological diseases has been studied (Patent Document 1-3). These diseases AMPA receptor for a review of the relationship between, and in the brain AMPA receptor obtained in the evaluation of the distribution. However, these AMPA receptor and the like in order to investigate, at this point in time must be postmortem brain, and normal volunteers do not make it possible a comparison of various problems.
Molecular imaging method, for example, positron emission tomography (PET) is, the movement of molecules of in vivo can be visualized by the in vivo method. AMPA receptors in the living body in order to visualize the behavior of the in vivo, so far, some of the synthesized molecule probe (non-patent document 1-3). However, the probe is the conventional molecules, specific binding to the receptor AMPA is insufficient or, brain or low migration of the probe reasons, these can be used for in vivo imaging of the receptors AMPA is difficult. Therefore, that specifically binds to AMPA receptors, indicating high integrated in the brain development of new compounds has been demanded.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY
  • NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY
  • 発明者(英語)
  • TAKAHASHI Takuya
  • MIYAZAKI Tomoyuki
  • SUHARA Tetsuya
  • HIGUCHI Makoto
  • CHO Meiei
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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