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NOVEL COMPOUND THAT SPECIFICALLY BINDS TO AMPA RECEPTOR

Foreign code F170009020
File No. (S2015-1685-N0)
Posted date Mar 29, 2017
Country WIPO
International application number 2016JP069896
International publication number WO 2017006931
Date of international filing Jul 5, 2016
Date of international publication Jan 12, 2017
Priority data
  • P2015-135124 (Jul 6, 2015) JP
Title NOVEL COMPOUND THAT SPECIFICALLY BINDS TO AMPA RECEPTOR
Abstract The present invention provides a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. This compound is capable of specifically binding to an AMPA receptor, and shows extremely high brain uptake. (In the formula, each of A and Z independently represents CO, SO or SO2; each of X and Y independently represents S or O; each of R1-R4 independently represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group or a halogen group; each R5 independently represents an alkyl group, an alkenyl group, an alkynyl group or a halogen group; and n represents an integer of 0-4.)
Outline of related art and contending technology BACKGROUND ART
AMPA receptors are widely distributed in the nervous system, learning, memory, neurodegenerative, or the like and cell death are known to be involved. In recent years, targeted receptor AMPA, spirit, for the treatment of neurological diseases has been studied (Patent Document 1-3). These diseases AMPA receptor for a review of the relationship between, and in the brain AMPA receptor obtained in the evaluation of the distribution. However, these AMPA receptor and the like in order to investigate, at this point in time must be postmortem brain, and normal volunteers do not make it possible a comparison of various problems.
Molecular imaging method, for example, positron emission tomography (PET) is, the movement of molecules of in vivo can be visualized by the in vivo method. AMPA receptors in the living body in order to visualize the behavior of the in vivo, so far, some of the synthesized molecule probe (non-patent document 1-3). However, the probe is the conventional molecules, specific binding to the receptor AMPA is insufficient or, brain or low migration of the probe reasons, these can be used for in vivo imaging of the receptors AMPA is difficult. Therefore, that specifically binds to AMPA receptors, indicating high integrated in the brain development of new compounds has been demanded.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY
  • NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY
  • Inventor
  • TAKAHASHI Takuya
  • MIYAZAKI Tomoyuki
  • SUHARA Tetsuya
  • HIGUCHI Makoto
  • CHO Meiei
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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