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HOST REGULATION FACTOR FOR ENHANCING PROLIFERATION AND PROPAGATION OF VACCINIA VIRUS

Foreign code F170009025
File No. (S2015-1760-N0)
Posted date Mar 29, 2017
Country WIPO
International application number 2016JP071538
International publication number WO 2017014296
Date of international filing Jul 22, 2016
Date of international publication Jan 26, 2017
Priority data
  • P2015-145153 (Jul 22, 2015) JP
Title HOST REGULATION FACTOR FOR ENHANCING PROLIFERATION AND PROPAGATION OF VACCINIA VIRUS
Abstract The objective of the present invention is to provide a use for a UCA1 gene, which is a host regulation factor that enhances proliferation and propagation of the vaccinia virus, so that cancer virotherapy using the vaccinia virus can be effectively carried out. The present invention is: a method for making a predictive evaluation of the efficacy of a cancer treatment using the vaccinia virus, by measuring the expression of the UCA1 gene in cancer cells of a cancer patient, and if the UCA1 gene is expressed, predicting that a cancer treatment using the vaccinia virus will be effective in the patient; and a vaccinia virus introduced in a manner enabling UCA1 gene expression.
Outline of related art and contending technology BACKGROUND ART
In recent years, the treatment of cancer virus viral treatment of cancer in a variety of techniques have been developed. Such as used in the treatment of virus, adenovirus, retrovirus other, is vaccinia virus.
Vaccinia virus in recent years, its wide host range and high expression efficiency characteristics, the foreign gene has been introduced as an expression vector for infection (HIV and SARS) have also been used as a multivalent vaccine.
In addition, the solubility of vaccinia virus using cancer cells, the technique used for the treatment of cancer have been reported (see patent document 1 and patent document 2).
In embryo development and tumor formation as the genes responsible for the UCA1 have been reported (non-patent document 1 - see non-patent document 4). UCA1(Urothelial cancer associated 1) gene, encodes a protein that is not a long-chain noncoding RNA(long-non coding RNA: lncRNA) and, used as a marker of bladder cancer and the like have been reported.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY
  • Inventor
  • NAKAMURA Takafumi
  • HORITA Kousuke
  • KUROSAKI Hajime
  • NAKATAKE Motomu
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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