HOST REGULATION FACTOR FOR ENHANCING PROLIFERATION AND PROPAGATION OF VACCINIA VIRUS
|Posted date||Mar 29, 2017|
|International application number||2016JP071538|
|International publication number||WO 2017014296|
|Date of international filing||Jul 22, 2016|
|Date of international publication||Jan 26, 2017|
|Title||HOST REGULATION FACTOR FOR ENHANCING PROLIFERATION AND PROPAGATION OF VACCINIA VIRUS|
|Abstract||The objective of the present invention is to provide a use for a UCA1 gene, which is a host regulation factor that enhances proliferation and propagation of the vaccinia virus, so that cancer virotherapy using the vaccinia virus can be effectively carried out. The present invention is: a method for making a predictive evaluation of the efficacy of a cancer treatment using the vaccinia virus, by measuring the expression of the UCA1 gene in cancer cells of a cancer patient, and if the UCA1 gene is expressed, predicting that a cancer treatment using the vaccinia virus will be effective in the patient; and a vaccinia virus introduced in a manner enabling UCA1 gene expression.|
|Outline of related art and contending technology||
In recent years, the treatment of cancer virus viral treatment of cancer in a variety of techniques have been developed. Such as used in the treatment of virus, adenovirus, retrovirus other, is vaccinia virus.
Vaccinia virus in recent years, its wide host range and high expression efficiency characteristics, the foreign gene has been introduced as an expression vector for infection (HIV and SARS) have also been used as a multivalent vaccine.
In addition, the solubility of vaccinia virus using cancer cells, the technique used for the treatment of cancer have been reported (see patent document 1 and patent document 2).
In embryo development and tumor formation as the genes responsible for the UCA1 have been reported (non-patent document 1 - see non-patent document 4). UCA1(Urothelial cancer associated 1) gene, encodes a protein that is not a long-chain noncoding RNA(long-non coding RNA: lncRNA) and, used as a marker of bladder cancer and the like have been reported.
|IPC(International Patent Classification)||
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
Contact Information for " HOST REGULATION FACTOR FOR ENHANCING PROLIFERATION AND PROPAGATION OF VACCINIA VIRUS "
- Japan Tottori University Organization for Regional Industrial Academic Cooperation Division of Intellectual Property Management and Operation
- URL: http://www.cjrd.tottori-u.ac.jp/
- Address: 101,Minami4-chome,Koyama-cho,Tottori-shi,Tottori,Japan , 680-8550
- Phone: 81-857-31-6000
- Fax: 81-857-31-5474