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SUPPRESSION AND REGENERATION PROMOTING EFFECT OF LOW MOLECULAR WEIGHT COMPOUND ON CANCER AND FIBROSIS

外国特許コード F170009026
整理番号 (S2015-2042-N0)
掲載日 2017年3月29日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP077475
国際公開番号 WO 2017047762
国際出願日 平成28年9月16日(2016.9.16)
国際公開日 平成29年3月23日(2017.3.23)
優先権データ
  • 特願2015-185988 (2015.9.18) JP
発明の名称 (英語) SUPPRESSION AND REGENERATION PROMOTING EFFECT OF LOW MOLECULAR WEIGHT COMPOUND ON CANCER AND FIBROSIS
発明の概要(英語) The purpose of the present invention is to obtain a novel treatment drug for a malignant tumor or fibrosis. The present invention uses the compounds expressed in formula (1), or salts thereof, or solvates thereof. Or, the present invention uses a treatment drug for a malignant tumor or a treatment drug for fibrosis that includes the compounds expressed in formula (1), or salts thereof, or solvates thereof.
従来技術、競合技術の概要(英語) BACKGROUND ART
As human causes the death of, malignant tumors, heart disease, cerebrovascular disease and diseases such as at the higher level. Among these malignant tumor is, because of the complexity of the pathogenesis, especially in the prevention and treatment of said disease difficult.
As the cause of the symptoms of the malignant tumor, and tissue fibrosis. For example, with the progress of the fibrosis of the liver, liver cirrhosis, liver cancer. Other, fibrosis of the lung, kidney, heart, and may occur such as the skin. Non-patent document 1 is, as the treatment of fibrosis, pirfenidone results of clinical trials is described.
The inventors have found that, with respect to a low-molecular compound, and one report 3 (non-patent document 2, 3, patent document 1). Non-patent document 2, is 3, and anti-proliferative effect in liver cancer cells Wnt / β - catenin signaling suppressive effect of small molecule compounds described. Document 2, is 3, any structure and function to liver cancer cells and a compound having a cytostatic effect is not described.
Is Patent Document 1, PN-1-2, PN-3-4, PN-3-13, HC-1, and IC-2 is, of the mesenchymal stem cells suppressed Wnt / β - catenin signaling, mesenchymal stem cells and to induce the differentiation of liver cells is described. In this document, is not described for inhibiting growth of cancer cells.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY
  • 発明者(英語)
  • SHIOTA, Goshi
  • ITABA, Noriko
  • MORIMOTO, Minoru
  • OKA, Hiroyuki
  • ABE, Kenichiro
  • SHIMIZU, Hiroki
  • KOUNO, Yohei
  • YOKOGI, Satoshi
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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