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SUPPRESSION AND REGENERATION PROMOTING EFFECT OF LOW MOLECULAR WEIGHT COMPOUND ON CANCER AND FIBROSIS

Foreign code F170009026
File No. (S2015-2042-N0)
Posted date Mar 29, 2017
Country WIPO
International application number 2016JP077475
International publication number WO 2017047762
Date of international filing Sep 16, 2016
Date of international publication Mar 23, 2017
Priority data
  • P2015-185988 (Sep 18, 2015) JP
Title SUPPRESSION AND REGENERATION PROMOTING EFFECT OF LOW MOLECULAR WEIGHT COMPOUND ON CANCER AND FIBROSIS
Abstract The purpose of the present invention is to obtain a novel treatment drug for a malignant tumor or fibrosis. The present invention uses the compounds expressed in formula (1), or salts thereof, or solvates thereof. Or, the present invention uses a treatment drug for a malignant tumor or a treatment drug for fibrosis that includes the compounds expressed in formula (1), or salts thereof, or solvates thereof.
Outline of related art and contending technology BACKGROUND ART
As human causes the death of, malignant tumors, heart disease, cerebrovascular disease and diseases such as at the higher level. Among these malignant tumor is, because of the complexity of the pathogenesis, especially in the prevention and treatment of said disease difficult.
As the cause of the symptoms of the malignant tumor, and tissue fibrosis. For example, with the progress of the fibrosis of the liver, liver cirrhosis, liver cancer. Other, fibrosis of the lung, kidney, heart, and may occur such as the skin. Non-patent document 1 is, as the treatment of fibrosis, pirfenidone results of clinical trials is described.
The inventors have found that, with respect to a low-molecular compound, and one report 3 (non-patent document 2, 3, patent document 1). Non-patent document 2, is 3, and anti-proliferative effect in liver cancer cells Wnt / β - catenin signaling suppressive effect of small molecule compounds described. Document 2, is 3, any structure and function to liver cancer cells and a compound having a cytostatic effect is not described.
Is Patent Document 1, PN-1-2, PN-3-4, PN-3-13, HC-1, and IC-2 is, of the mesenchymal stem cells suppressed Wnt / β - catenin signaling, mesenchymal stem cells and to induce the differentiation of liver cells is described. In this document, is not described for inhibiting growth of cancer cells.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY
  • Inventor
  • SHIOTA, Goshi
  • ITABA, Noriko
  • MORIMOTO, Minoru
  • OKA, Hiroyuki
  • ABE, Kenichiro
  • SHIMIZU, Hiroki
  • KOUNO, Yohei
  • YOKOGI, Satoshi
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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