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NON-HUMAN ANIMAL MODEL OF CANCER AND METHOD FOR CONSTRUCTING SAME, CANCER STEM CELL AND METHOD FOR PRODUCING SAME UPDATE 新技術説明会

外国特許コード F170009063
整理番号 S2017-0045-N0
掲載日 2017年5月17日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP060309
国際公開番号 WO 2016170938
国際出願日 平成28年3月30日(2016.3.30)
国際公開日 平成28年10月27日(2016.10.27)
優先権データ
  • 特願2015-085851 (2015.4.20) JP
発明の名称 (英語) NON-HUMAN ANIMAL MODEL OF CANCER AND METHOD FOR CONSTRUCTING SAME, CANCER STEM CELL AND METHOD FOR PRODUCING SAME UPDATE 新技術説明会
発明の概要(英語) Provided is a non-human animal model of cancer that is constructed by transplanting a cancer stem cell, said cancer stem cell having characteristics of an organ or tissue, into a non-human mammal so as to induce cancer of the organ or tissue therein.
従来技術、競合技術の概要(英語) BACKGROUND ART
Of the subject material is a carcinogenic risk assessment, mutagenic test or repeat-dose toxicology study, statistical evaluation of the effect of the human or the like has been carried out. However, in recent years cancer study of cancer and cancer tissues of a particular gene mutation only by the uniform collection of cells of the present invention is, heterogeneous nature, have a characteristic in a population of cells, 'cancer-induced micro-environment' the basis of the cancer by 'a cancer stem cell' are created, a cancer stem cell proliferation and differentiation, growth or metastasis of the cancerous tissue infiltration, the, recurrence of the cancer treatment is the cause of failure has been revealed. A cancer stem cell differentiation is unlimited continuously produce cancer cells, proliferate itself. This differentiation promoting the growth of providing a detectable signal in the microenvironment (niche). On the other hand, in the course of this differentiation is not yet been elucidated in detail, the inventors have found that by using iPS cells, cancer derived cell line culture broth to induce cancer stem cell is "niche" has been verified the presence of the (patent document 1).
Conventional, the model of cancer, for example human cancers of the nude mice, skid such as a mouse subcutaneously in immune-compromised mice can be made has been used.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
  • 発明者(英語)
  • SENO, Masaharu
  • KASAI, Tomonari
  • IWASAKI, Yoshiaki
  • OHARA, Toshiaki
  • HIROHATA, Satoshi
  • KAKUTA, Hiroki
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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