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NANO-FLUID DEVICE AND CHEMICAL ANALYSIS APPARATUS

Foreign code F170009068
File No. (AF46P001)
Posted date May 29, 2017
Country WIPO
International application number 2016JP081315
International publication number WO 2017069256
Date of international filing Oct 21, 2016
Date of international publication Apr 27, 2017
Priority data
  • P2015-209235 (Oct 23, 2015) JP
Title NANO-FLUID DEVICE AND CHEMICAL ANALYSIS APPARATUS
Abstract This nano-fluid device is provided with a first substrate having a nanoscale groove in one surface thereof, and a second substrate for forming a nano-flow channel with the groove of the first substrate, the second substrate being provided integrally with the first substrate so that faces thereof are joined together, wherein either the first substrate or the second substrate is provided at least with a thin-walled part in a portion at a position overlapping with the nano-flow channel in plan view, and the thin-walled part deforms by pressure thereon and opens and closes the nano-flow channel.
Outline of related art and contending technology BACKGROUND ART
Conventional, the fine space is laminar, mixing, reaction time can be shortened, the sample, a substantial reduction in the amount of reagent, and the like of the to be realized by a small device, diagnostic, and analyzing are expected to be used in the art. For example, the angle of a few centimeters on the glass substrate (microchip), or less than the depth of the groove of the several hundred µm microchannel is formed, the chemical system that has the known device.
Chemistry system 1 are integrated as one element of the device, such as a valve to control fluid can be of a device. Valve can be incorporated into a device, the micro-channels of the fluid flow direction and defines, the flow of fluid itself can be controlled.
For example, in Non-Patent Document 1, a soft polymer material such as dimethylpolysiloxane (PDMS) using a change in shape, and closing the micro flow path in which the device is described.
For example, to Patent Document 1, which is provided with a hollow portion of the glass substrate is used, the volume of the hollow portion of the fluid at the microscale can be controlled by a fluid control valve is provided which device is described.
Incidentally, in recent years, micro-scale fine space scale is reduced further having a nanoscale space has been studied.
The space having a nanoscale, smaller size than a single cell, single cell analysis device which is expected to be also used. For example, several dozen µm the size of the proteins in one cell and the like, so that a smaller size than the extension of a few hundred nm to several tens nano-space - is analyzed, the average of the multiple cells far been unable to each cell the function of the analysis becomes possible. For example, the initial cancer diagnosis or the like that is generated can be carried out is one of cancer cells is expected.
Further, the nano-scale fine space based devices, ultra-high sensitivity to the analytical tool is also expected. In this way, by using a nano-space is expanded, high sensitivity, high-speed chromatography, are countable a single molecule or molecules (of the order of counted molecules) of the immunoassay can be realized.
The influence of the surface of the dominant signal space having a nanoscale, microscale the solution properties as compared with a minute space according to the specific nature. Therefore, this unique solution properties using a new device has attracted attention.
- Several tens nm to several hundreds of such expansion of the innovative use of a nano-space is also in a device function, the fluid flowing in a microchannel to a demand control. For example, in Non-Patent Document 2, the hydrophobic nano-flow path is provided with a hydrophilic moiety, using the Laplace pressure of these interfaces are described with a stop valve.
Scope of claims (In Japanese)[請求項1]
一面にナノスケールの溝を有する第1基板と、該第1基板と互いの一面同士を接合して一体に設けられ、前記第1基板の溝とともにナノ流路を形成する第2基板とを備えたナノ流体デバイスであって、
前記第1基板または前記第2基板のいずれか一方は、平面視して前記ナノ流路と重なる位置の一部に少なくとも薄肉部を備え、
前記薄肉部が押圧によって変形して前記ナノ流路を開閉するナノ流体デバイス。
[請求項2]
前記薄肉部の厚みが10mm以下である請求項1に記載のナノ流体デバイス。
[請求項3]
前記薄肉部のナノ流路が延在する方向の幅が2~100μmである請求項1または2のいずれかに記載のナノ流体デバイス。
[請求項4]
前記第1基板及び前記第2基板により構成される前記ナノ流路は、一方向に延在する流路部と、平面視で前記薄肉部と重なる位置に設けられ、前記ナノ流路より幅が広い動作領域と、を備える請求項1~3のいずれか一項に記載のナノ流体デバイス。
[請求項5]
前記第1基板または前記第2基板のうち、前記薄肉部を備えない方の基板が、前記薄肉部に相対する前記ナノ流路内の位置に、変形した薄肉部が当たる突起部を有する請求項1~4のいずれか一項に記載のナノ流体デバイス。
[請求項6]
前記第1基板または前記第2基板のうち、前記薄肉部を備えない方の基板が、前記薄肉部に相対する前記ナノ流路内の位置に、変形した薄肉部の形状に合わせた凹部を有する請求項1~5のいずれか一項に記載のナノ流体デバイス。
[請求項7]
前記押圧を行う押圧機構を備えた請求項1~6のいずれか一項に記載のナノ流体デバイス。
[請求項8]
請求項1~7のいずれか一項に記載のナノ流体デバイスを備えた化学分析装置。
[請求項9]
請求項1~7のいずれか一項に記載のナノ流体デバイスと、該ナノ流体デバイスを挟むように配置されたマイクロスケールのマイクロ流路を有する2つ以上のマイクロ流路デバイスとを備え、
前記ナノ流体デバイスと前記2つ以上のマイクロ流路デバイスのそれぞれとは、前記ナノ流路と前記マイクロ流路との連通によって連結され、
前記ナノ流体デバイスで化学分析を行うことができる化学分析装置。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • KAZOE Yutaka
  • PIHOSH Yuriy
  • KITAMORI Takehiko
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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