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ECTOPIC OSSIFICATION TREATMENT DRUG HAVING MECHANISM FOR BLOCKING PAR1 UPDATE

外国特許コード F170009105
整理番号 (S2016-0190-N0)
掲載日 2017年6月15日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP084101
国際公開番号 WO 2017086385
国際出願日 平成28年11月17日(2016.11.17)
国際公開日 平成29年5月26日(2017.5.26)
優先権データ
  • 特願2015-228232 (2015.11.20) JP
発明の名称 (英語) ECTOPIC OSSIFICATION TREATMENT DRUG HAVING MECHANISM FOR BLOCKING PAR1 UPDATE
発明の概要(英語) [Problem] To further reveal the pathologic mechanism in an FOP patient, and to develop a novel treatment drug, a novel treatment method, a novel diagnosis method, etc., making use of the obtained finding. [Solution] The inventors have found that, in FOP, ectopic ossification, which occurs as a result of an inflammation due to an external injury, etc., is mediated through PAR1. The inventors have completed, from this finding, the present invention pertaining to a drug, etc., characterized by inhibiting ectopic ossification in FOP by blocking PAR1.
特許請求の範囲(英語) [claim1]
1. Inhibiting PAR1, for treating or preventing ectopic ossification agent characterized in that it is not
[claim2]
2. PAR1 Inhibition, an antagonist of PAR1 according to claim 1 characterized in that the agent is performed by
[claim3]
3. PAR1 {(1E) -2-[5-(3-fluorophenyl) pyridin-2-yl]ethen-1-yl} -1-methyl-3-oxododecahydronaphtho[ 2,3-c]furan-6-yl]carbamate, ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS) -9- antagonist or its salt according to claim 2 characterized in that the medicament
[claim4]
4. Is ectopic ossification, progressive skeletal dysplasia symptoms in bone in claim 1 from 3 characterized in that the agent
[claim5]
5. Using the agent of claim claims 1-4, ectopic ossification and preventing treatment is not
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KUMAMOTO UNIVERSITY
  • 発明者(英語)
  • ERA TAKUMI
  • KITO TAKAYUKI
国際特許分類(IPC)
指定国 (WO201786385)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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