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ECTOPIC OSSIFICATION TREATMENT DRUG HAVING MECHANISM FOR BLOCKING PAR1

Foreign code F170009105
File No. (S2016-0190-N0)
Posted date Jun 15, 2017
Country WIPO
International application number 2016JP084101
International publication number WO 2017086385
Date of international filing Nov 17, 2016
Date of international publication May 26, 2017
Priority data
  • P2015-228232 (Nov 20, 2015) JP
Title ECTOPIC OSSIFICATION TREATMENT DRUG HAVING MECHANISM FOR BLOCKING PAR1
Abstract [Problem] To further reveal the pathologic mechanism in an FOP patient, and to develop a novel treatment drug, a novel treatment method, a novel diagnosis method, etc., making use of the obtained finding. [Solution] The inventors have found that, in FOP, ectopic ossification, which occurs as a result of an inflammation due to an external injury, etc., is mediated through PAR1. The inventors have completed, from this finding, the present invention pertaining to a drug, etc., characterized by inhibiting ectopic ossification in FOP by blocking PAR1.
Scope of claims [claim1]
1. Inhibiting PAR1, for treating or preventing ectopic ossification agent characterized in that it is not
[claim2]
2. PAR1 Inhibition, an antagonist of PAR1 according to claim 1 characterized in that the agent is performed by
[claim3]
3. PAR1 {(1E) -2-[5-(3-fluorophenyl) pyridin-2-yl]ethen-1-yl} -1-methyl-3-oxododecahydronaphtho[ 2,3-c]furan-6-yl]carbamate, ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS) -9- antagonist or its salt according to claim 2 characterized in that the medicament
[claim4]
4. Is ectopic ossification, progressive skeletal dysplasia symptoms in bone in claim 1 from 3 characterized in that the agent
[claim5]
5. Using the agent of claim claims 1-4, ectopic ossification and preventing treatment is not
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KUMAMOTO UNIVERSITY
  • Inventor
  • ERA TAKUMI
  • KITO TAKAYUKI
IPC(International Patent Classification)
Specified countries (WO201786385)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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