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Semiconductor nanoparticles and fluorescent probe for biological labeling commons

Foreign code F170009122
File No. C20130206US#P01
Posted date Jul 12, 2017
Country United States of America
Application number 201314056329
Gazette No. 20140284528
Gazette No. 9535006
Date of filing Oct 17, 2013
Gazette Date Sep 25, 2014
Gazette Date Jan 3, 2017
Priority data
  • P2013-060365 (Mar 22, 2013) JP
Title Semiconductor nanoparticles and fluorescent probe for biological labeling commons
Abstract (US9535006)
Semiconductor nanoparticles of the present invention are particles each having a core-shell structure that includes a core and a shell surrounding the core.
The core includes (AgIn)xZn2(1-x)S2 (0.4≦x≦0.95 holds).
The shell includes ZnS or ZnO, and the semiconductor nanoparticles each have at least one hydrophilic functional group on a surface of the shell.
As the hydrophilic functional group, for example, a carboxyl group or a sulfo group may be mentioned.
Since having a low toxicity and a high emission quantum yield, the semiconductor nanoparticles as described above may be used for a fluorescent probe for biological labeling.
Scope of claims [claim1]
1. Semiconductor nanoparticles each having a core-shell structure that includes a core and a shell surrounding the core, wherein the core includes (AgIn)xZn2(1-x)S2 (0.4 <= * <= 0.95),
the shell includes ZnS or ZnO, and
the semiconductor nanoparticles each have a hydrophilic functional group on a surface of the shell.
[claim2]
2. The semiconductor nanoparticles according to claim 1, wherein 0.8 <= x <= 0.9.
[claim3]
3. A fluorescent probe for biological labeling, comprising: conductor nanoparticles according to claim 2.
[claim4]
4. The semiconductor nanoparticles according to claim 1, wherein the hydrophilic functional group is a carboxyl group or its salt or a sulfo group or its salt.
[claim5]
5. The semiconductor nanoparticles according to claim 4, wherein the hydrophilic functional group is a functional group of a bifunctional molecule having said hydrophilic functional group (first functional group) and a functional group (second functional group) which is bonded to the surface of the shell.
[claim6]
6. The semiconductor nanoparticles according to claim 5, wherein the second functional group contains a sulfur atom or a nitrogen atom.
[claim7]
7. The semiconductor nanoparticles according to claim 6, wherein the second functional group contains a sulfur atom and is a mercapto group; a group having a disulfide bond; a group having a sulfide bond; a pyridylthio group; or a dithiocarboxyl group.
[claim8]
8. A fluorescent probe for biological labeling, comprising: conductor nanoparticles according to claim 7.
[claim9]
9. The semiconductor nanoparticles according to claim 6, wherein the second functional group contains a nitrogen atom and is an imino group, an amide group, an imide group, or a pyridyl group.
[claim10]
10. A fluorescent probe for biological labeling, comprising: conductor nanoparticles according to claim 9.
[claim11]
11. A fluorescent probe for biological labeling, comprising: conductor nanoparticles according to claim 6.
[claim12]
12. The semiconductor nanoparticles according to claim 5, wherein the bifunctional molecule is 3-mercaptopropionic acid, 4-mercaptobutyric acid, 2-mercaptomethane sulfonic acid, 2-mercaptoethane sulfonic acid, 3-mercaptopropane sulfonic acid, or 2-mercaptoethane sodium sulfonate.
[claim13]
13. A fluorescent probe for biological labeling, comprising: conductor nanoparticles according to claim 12.
[claim14]
14. A fluorescent probe for biological labeling, comprising: conductor nanoparticles according to claim 5.
[claim15]
15. A fluorescent probe for biological labeling, comprising: conductor nanoparticles according to claim 4.
[claim16]
16. A fluorescent probe for biological labeling, comprising: the semiconductor nanoparticles according to claim 1.
  • Inventor, and Inventor/Applicant
  • YUKAWA HIROSHI
  • NISHI HIROYASU
  • TORIMOTO TSUKASA
  • BABA YOSHINOBU
  • NAGOYA UNIVERSITY
IPC(International Patent Classification)
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