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PROCESS FOR STABILIZING TARGET-BINDING PEPTIDE

外国特許コード F170009128
整理番号 (S2015-2115-N0)
掲載日 2017年7月20日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP089017
国際公開番号 WO 2017115828
国際出願日 平成28年12月28日(2016.12.28)
国際公開日 平成29年7月6日(2017.7.6)
優先権データ
  • 特願2015-257646 (2015.12.29) JP
発明の名称 (英語) PROCESS FOR STABILIZING TARGET-BINDING PEPTIDE
発明の概要(英語) The objective of the invention is to provide a process for suppressing the fluctuations of a target-binding peptide, in other words, to provide a process for stabilizing a target-biding peptide. The above-mentioned problem can be solved by a process for stabilizing a target-binding peptide characterized in that, when a substitution region with a root mean square fluctuation value of 1.5Å or less in a structure containing the scaffold protein loop of the present invention, is substituted by base peptides: alanine peptides, glycine peptides, proline peptides, and serine peptides, the root mean square fluctuation value of these peptides in the scaffold protein is 1.5Å or less, and said substitution region is substituted by a target-binding peptide constituted of 3 to 15 amino acids.
従来技術、競合技術の概要(英語) BACKGROUND ART
Recently, biotechnology technology to the peptide, nucleic acid, such as by using the bio-development of a drug or protein has been promoted. For example, antibody pharmaceuticals, or active site peptide designed around a pharmaceutical and the like are developed, their active substance, binding of a target molecule is, for example by using a variety of analytes is being analyzed. In these biopharmaceuticals, the first generation of peptide pharmaceuticals, such as a hormone secreted in the human body (amino acid condensate of a) a physiologically active substance is used as a pharmaceuticals was, in recent years as described above by designing the active site, the phage display method or the like and screened by, further excellent peptide binding activity for a target molecule has been the development of a drug. Such a target molecule that binds specifically binds strongly to the target binding peptide (functional peptide) as well as the therapeutic agent is, also holds great promise as a diagnostic agent, an excellent target for the selection of the binding peptide is expected.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOKYO INSTITUTE OF TECHNOLOGY
  • 発明者(英語)
  • KADONOSONO Tetsuya
  • KONDOH Shinae
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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