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PLANAR PATCH CLAMP DEVICE AND PLANAR PATCH CLAMP SYSTEM

Foreign code F170009137
File No. AF19-07WO
Posted date Aug 8, 2017
Country WIPO
International application number 2014JP072808
International publication number WO 2015030201
Date of international filing Aug 29, 2014
Date of international publication Mar 5, 2015
Priority data
  • P2013-180684 (Aug 30, 2013) JP
Title PLANAR PATCH CLAMP DEVICE AND PLANAR PATCH CLAMP SYSTEM
Abstract A planar patch clamp device comprising: an electrically non-conductive substrate (2) having a through-hole (3) which passes liquid yet does not pass cells in a cell arrangement region (4); a first liquid reservoir unit (6) for holding a first electroconductive liquid, the first liquid reservoir unit (6) being provided so as to allow communication with the through-hole (3) on a first surface (2S) of the substrate (2); a first electrode unit (7) arranged so as to allow electrical conductivity with the first liquid reservoir unit (6); a second liquid reservoir unit (6') for holding a second electroconductive liquid, the second liquid reservoir unit (6) being provided so as to allow communication with the through-hole (3) on a second surface (2S') of the substrate (2); a second electrode unit (7') arranged so as to allow electrical conductivity with the first liquid reservoir unit (6); a liquid feed channel (8) for feeding the second electroconductive liquid to the second liquid reservoir unit (6'); a liquid discharge channel (9) for discharging the second electroconductive liquid from the second liquid reservoir unit (6'); and a valve (10) disposed in the liquid feed channel (8) and/or the liquid discharge channel (9), the valve (10) being capable of permitting or stopping the distribution of the second electroconductive liquid, and permitting or stopping electrical conductivity with the second liquid reservoir unit (6') and the second electrode unit (7').
Scope of claims [claim1]
1. As it possesses the second surface which is the first surface and its opposite aspect which possess the cell arrangement territory, the cell is not made to pass inside the cell arrangement territory, but the electric insulated baseplate which possesses the perforation hole which can make the liquid pass and,
The first liquid *** section in order the perforation hole and communication is provided possibly on first surface side of the electric insulated baseplate, to keep the first conductive liquid and,
The first liquid *** section and through the first conductive liquid, electric continuity the first electrode section which possibly is arranged and,
The second liquid *** section in order the perforation hole and communication is provided possibly on second surface side of the electric insulated baseplate, to keep the second conductive liquid and,
The second liquid *** section and through the second conductive liquid, electric continuity the second electrode section which possibly is arranged and,
The sending liquid passage which is connected by the second liquid *** section, in the second liquid *** section the sending liquid it does the second conductive liquid and,
The drainage passage which is connected by the second liquid *** section, from the second liquid *** section the drainage it does the second conductive liquid and,
As the sending liquid passage and/or it is provided in the drainage passage, or can allow stop the circulation of the second conductive liquid, electric continuity of the second liquid *** section and the second electrode section the valve which or it can allow stop
It possesses, the planar patch clamp device.
[claim2]
2. As the electric insulated baseplate plural has the cell arrangement territory and corresponds to that the perforation hole which respectively, corresponding to the plural cell arrangement territories, the plural providing the second liquid *** section,
The plural sending liquid tributary roads where the sending liquid passage, diverges from the sending liquid main passage, and the sending liquid main passage is connected to the plural second liquid *** sections respectively possessing,
The drainage passage, the drainage main passage where the plural drainage tributary roads and the plural drainage tributary roads which are respectively connected to the plural second liquid *** sections flow together possessing,
Second electrode section, sending liquid main passage and/or providing to drainage main passage,
Each sending liquid tributary road and/or it can provide the valve, in each drainage tributary road,
In claim 1 planar patch clamp device of statement.
[claim3]
3. Electric value of resistance of the valve front and back in the time of valve closing is 1 megohms or more, in claim 1 or 2 the planar patch clamp device of statement.
[claim4]
4. Either of claim 1-3 in one section planar patch clamp device of statement and,
The control section which controls opening and closing each valve of the aforementioned planar patch clamp device and,
The electric sensing station which detects the electric information in each electrode section of the aforementioned planar patch clamp device
The planar patch clamp system which it has.
[claim5]
5. Plural it has the aforementioned planar patch clamp device, in claim 4 the planar patch clamp system of statement.
[claim6]
6. Furthermore it has the optical sensing station which detects the light information which is derived from the cell which is arranged in the aforementioned planar patch clamp device, in claim 4 or 5 the planar patch clamp system of statement.
[claim7]
7. Either of the claim 1-3 in one section the planar patch clamp device of statement, or either of the claim 4-7 in 1 sections the method the screening of doing the medicine which produces effect on nervous network making use of the planar patch clamp system of statement.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • URISU TSUNEO
  • WANG ZHI-HONG
  • UNO HIDETAKA
  • NAGAOKA YASUTAKA
  • KOBAYASHI KEI
IPC(International Patent Classification)
Specified countries (WO201530201)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
Reference ( R and D project ) CREST Creation of Nanosystems with Novel Functions through Process Integration AREA
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