TOP > 外国特許検索 > LITHOCHOLIC ACID DERIVATIVE HAVING VITAMIN D ACTIVITY

LITHOCHOLIC ACID DERIVATIVE HAVING VITAMIN D ACTIVITY コモンズ 新技術説明会

外国特許コード F170009150
整理番号 (S2016-0294-N0)
掲載日 2017年8月16日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP002902
国際公開番号 WO 2017131144
国際出願日 平成29年1月27日(2017.1.27)
国際公開日 平成29年8月3日(2017.8.3)
優先権データ
  • 特願2016-014012 (2016.1.28) JP
発明の名称 (英語) LITHOCHOLIC ACID DERIVATIVE HAVING VITAMIN D ACTIVITY コモンズ 新技術説明会
発明の概要(英語) The objective of the present invention is to provide: a novel lithocholic acid derivative having vitamin D activity; and a pharmaceutical product, a vitamin D receptor activator and a prophylactic and/or therapeutic agent for vitamin D receptor-related diseases, each of which contains the lithocholic acid derivative. The present invention provides a lithocholic acid derivative which has a hydroxyalkyl group in the 3-position, a salt thereof or a prodrug thereof.
従来技術、競合技術の概要(英語) BACKGROUND ART
Vitamin D is, body metabolic activation 1 α, 25 - dihydroxyvitamin D3 receptor (VDR) is coupled to vitamin D, which controls the expression of specific genes. Under the control of the expression of this gene, vitamin D is, to maintain the calcium concentration in the blood, bone formation, immune function, cell differentiation, growth control responsible for the important physiological functions. So far, osteoporosis, psoriasis and cancer therapeutic agents such as for the purpose of development, a large number of VDR ligands have been developed, some of which are clinical application as a medicament. Many of the existing VDR ligand, in the natural form of 1 α, 25 - dihydroxyvitamin D3 has in the same manner as skeleton. skeleton, a derivative having a high activity useful in the development of, in general chemical stability is low, requires a complicated synthesis, various pharmaceutical applicability of the action of vitamin D is limited. Therefore, non- VDR ligand skeleton type but is desired to be developed, such non--type VDR ligand reported less.
Lithocholate, found to be the endogenous ligand VDR but, is very weak VDR affinity of lithocholic acid, the physiological significance is unknown. Patent Document 1 is, lithocholic acid propionate lithocholic acid derivative is able to activate the VDR is described, in non-patent document 1, lithocholic acid acetate and lithocholic acid propionate is described.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • OCHANOMIZU UNIVERSITY
  • NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
  • 発明者(英語)
  • TANATANI Aya
  • SASAKI Harue
  • KAWASAKI Haru
  • KAGECHIKA Hiroyuki
  • MASUNO Hiroyuki
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
※ 詳細内容の提供、各種連携等のご相談につきましては、「問合せ先」まで直接ご連絡ください。

PAGE TOP

close
close
close
close
close
close