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PREDICTIVE FACTOR AND TESTING METHOD FOR THE ONSET OF ARTERIOSCLEROTIC DISEASES

外国特許コード F170009162
整理番号 (S2016-0444-N0)
掲載日 2017年9月6日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP005836
国際公開番号 WO 2017142055
国際出願日 平成29年2月17日(2017.2.17)
国際公開日 平成29年8月24日(2017.8.24)
優先権データ
  • 特願2016-027867 (2016.2.17) JP
発明の名称 (英語) PREDICTIVE FACTOR AND TESTING METHOD FOR THE ONSET OF ARTERIOSCLEROTIC DISEASES
発明の概要(英語) The present invention provides a diagnostic marker and onset risk evaluation method for arteriosclerotic diseases. More specifically, the present invention provides a method for evaluating the onset risk of an arteriosclerotic disease, wherein the C5a protein in a blood sample is adopted as a diagnostic marker for the arteriosclerotic disease, and the method includes a step for measuring, in vitro , the amount of the C5a protein in a blood sample collected from a subject, and a step for evaluating the onset risk of arteriosclerosis or vascular inflammation in the subject by using the amount of the C5a protein as an indicator. This method is useful for evaluating the onset risk of an arteriosclerotic disease at an extremely early stage.
従来技術、競合技術の概要(英語) BACKGROUND ART
Arteriosclerosis is, the fatal myocardial infarction or cerebral infarction and also may cause a serious disease. The arteriosclerosis, hypertension, dyslipidemia, a condition in which the lifestyle-related diseases such as diabetes and the base, thereby impairing the quality of life, often fatal. Systemic arteriosclerosis as methods of monitoring, MRI (cerebral white matter lesions), echo blood vessels (carotid artery intima-media complex hyperplasia), the pulse wave velocity (PWV) measurement or the like is known, from these early onset of disease arteriosclerosis cannot be easily predicted (Non-Patent Document 1).
Conventional, such as LDL or HDL lipoproteins in blood is associated with the onset of atherosclerosis has been known (Non-Patent Document 2). In addition, the inflammatory marker CRP, IL-5 or other molecules for the treatment of coronary arteriosclerosis have been reported to be associated with (Patent Document 1, Non-Patent Document 3). In addition, excess lipid uptake is involved in the development of arteriosclerosis is considered, and high cholesterol levels in blood and atherosclerosis, the risk of myocardial infarction are known (Non-Patent Document 4). However, at present the reliability of the atherosclerosis in early marker is not present, there exists a need for such a disease and early marker.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
  • 発明者(英語)
  • YOSHIDA, Masayuki
  • OSAKA, Mizuko
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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