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REGULATORY T CELL ACTIVATOR, AND USE THEREOF

外国特許コード F170009276
整理番号 (S2016-0470-N0)
掲載日 2017年11月7日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP015767
国際公開番号 WO 2017183665
国際出願日 平成29年4月19日(2017.4.19)
国際公開日 平成29年10月26日(2017.10.26)
優先権データ
  • 特願2016-084170 (2016.4.20) JP
発明の名称 (英語) REGULATORY T CELL ACTIVATOR, AND USE THEREOF
発明の概要(英語) A regulatory T cell activator comprising a substance capable of inhibiting the binding between DNAX Accessory Molecule-1 (DNAM-1) and CD155.
従来技術、競合技術の概要(英語) BACKGROUND ART
After the blood transfusion or stem cell transplantation, graft versus host disease (graft-versus-host disease, GVHD) if the onset. Graft versus host disease is, the implant is present in the cells from the donor cell of the T cell activation caused by the injury to the recipient. In addition, are implanted into the donor organ transplant and the recipient may occur. For example, implanted cardiac, vascular grafts, such as in kidney transplant, cardiac transplantation, blood, kidney, and engraftment of a temporary, if it is found that separation or the like is gradually. For this reason, organ transplant rejection or graft versus host disease is demanded a technique for suppressing.
For example, to Patent Document 1, neutralizing antibodies against protein DNAM-1 mouse, in the mouse heart transplant, kidney transplant engraftment of a blood vessel or graft is maintained can be used as an agent is described.
DNAM-1 protein, a molecular weight of CD226 65kDa also referred to as a cell adhesion molecule belonging to the immunoglobulin superfamily. DNAM-1 the expression of protein, human and CD4 mouse+ Tcells, CD8+ Tcells, NK cells, macrophages, dendritic cells are found in a variety of immune cells. RefSeq ID of the human NP_001290547 and DNAM-1, RefSeq ID of the mouse NP_001034238 is in the DNAM-1. The inventors, previously, DNAM-1 protein, have been known as polio virus receptor CD155 is coupled to the clear. CD155 Is, belonging to the immunoglobulin superfamily is a transmembrane glycoprotein-I.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • UNIVERSITY OF TSUKUBA
  • 発明者(英語)
  • SHIBUYA Akira
  • SHIBUYA Kazuko
  • ABE Fumie
  • HIROCHIKA Rei
  • OKUMURA Genki
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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