TOP > 外国特許検索 > PHOSPHORYLATED SARM1, ANTIBODY, SARM1 PHOSPHORYLATION INHIBITOR, PROPHYLACTIC OR THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISEASES, SCREENING METHOD, MODIFIED SARM1, AND USE

PHOSPHORYLATED SARM1, ANTIBODY, SARM1 PHOSPHORYLATION INHIBITOR, PROPHYLACTIC OR THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISEASES, SCREENING METHOD, MODIFIED SARM1, AND USE

外国特許コード F170009277
整理番号 (S2016-0511-N0)
掲載日 2017年11月7日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP011418
国際公開番号 WO 2017164230
国際出願日 平成29年3月22日(2017.3.22)
国際公開日 平成29年9月28日(2017.9.28)
優先権データ
  • 特願2016-058130 (2016.3.23) JP
発明の名称 (英語) PHOSPHORYLATED SARM1, ANTIBODY, SARM1 PHOSPHORYLATION INHIBITOR, PROPHYLACTIC OR THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISEASES, SCREENING METHOD, MODIFIED SARM1, AND USE
発明の概要(英語) The present invention provides a phosphorylated SARM1 (Sterile alpha and TIR motif-containing protein 1) in which at least one Ser residue selected from the group consisting of position 54, position 548, and position 622 of SARM1 is phosphorylated.
従来技術、競合技術の概要(英語) BACKGROUND ART
May be a mitochondrial localization signal SARM1(Sterile alpha and TIR motif-containing protein 1) TIR 1 with one of the adapter proteins, composed of 724 amino acids. SARM1 Is mainly expressed in the cell of the nervous system (non-patent document 1) strong, ischemic nerve cell death or nerve can cause molecules of axonal degeneration has been reported (non-patent document 2, 3). This neuronal cell death can markedly the knockout of SARM1 can be suppressed, and the target SARM1 if the drug is to suppress neuronal cell death, Parkinson's disease and amyotrophic lateral sclerosis (ALS) and the like can be applied in the treatment of a variety of neurodegenerative disease believed (patent document 1). However SARM1 targeting agent is not present.
Is Patent Document 2-5, an inhibitor of CDK8 or CDK19 effective in the treatment of cancer are disclosed.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
  • 発明者(英語)
  • MURATA, Hitoshi
  • SAKAGUCHI, Masakiyo
  • KINOSHITA, Rie
  • YAMAMOTO, Kenichi
国際特許分類(IPC)

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