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CELL-EMBEDDED BEADS FOR HAIR REGENERATION AND METHOD FOR PRODUCING SAME, AND KIT FOR HAIR REGENERATION UPDATE

外国特許コード F180009318
整理番号 (S2016-0752-N0)
掲載日 2018年1月24日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP021770
国際公開番号 WO 2017217393
国際出願日 平成29年6月13日(2017.6.13)
国際公開日 平成29年12月21日(2017.12.21)
優先権データ
  • 特願2016-120808 (2016.6.17) JP
発明の名称 (英語) CELL-EMBEDDED BEADS FOR HAIR REGENERATION AND METHOD FOR PRODUCING SAME, AND KIT FOR HAIR REGENERATION UPDATE
発明の概要(英語) Provided are cell-embedded beads for hair regeneration having high hair-regenerating activity, and a method for producing the same. The cell-embedded beads for hair regeneration contain mesenchymal cells and biocompatible hydrogel. The method for producing cell-embedded beads for hair regeneration is a method provided with a cell-embedded cured gel formed body preparation step that prepares liquid droplets containing mesenchymal cells and biocompatible hydrogel, cures the biocompatible hydrogel, and prepares a cell-embedded cured gel formed body, and an aggregation step that suspension cultures the cell-embedded cured gel formed body and induces aggregation by the tractive force of the cells.
従来技術、競合技術の概要(英語) BACKGROUND ART
To establish enough for clinical application of regenerative medicine is hair follicles, hair follicles reproduction has a structure in which the normal tissue, hair implantation site is suitable for the bristles, is formed, needs to be extended. Ectoderm including skin appendages such as the hair of the appendages is, typically, in the embryonic, epithelial cells and mesenchymal cells and which is generated by the interaction. Ectodermal one of the appendages of the hair follicles, growth and regression of an individual over the lifetime (hair cycle) are repeated, the playback portion in the growth of hair, hair follicle organ development phase can be induced by molecular mechanism as is known. In addition, the hair in the reproduction period of the hair, mesenchymal cells induced by the papillary hair cells are considered. That is, in the growth phase, the hair follicles mesenchymal epithelial stem cells differentiated papillary hair cells by the cells induced by the hair portion is reproduced.
Toward the hair follicles to which the mesenchymal cell reproduction (papillary dermis and hair root sheath cell of the cell) by replacing the hair follicle and hair follicles reproduction of the variable region have the ability to induce angiogenesis hair follicles by mesenchymal cells, epithelial cells and mesenchymal cells and the reconstruction of hair follicles and the like have been attempted. Specifically, a plurality of kinds of cells derived from somatic Wnt signal active agent was added a mixed culture in culture can be used, such as a primitive method of forming a hair follicle organ (for example, see Patent Document 1.), Mesenchymal cells of the cell clump hair follicles (spheroid) epithelial cells outside of the sphere is adhered to a method of producing an artificial hair (for example, see Patent Document 2.), And a hair disc cells and epithelial cells and is implanted with the spheroids, a reproduction method of the hair (for example, see Non-Patent Document 1.) And the like.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • YOKOHAMA NATIONAL UNIVERSITY
  • 発明者(英語)
  • FUKUDA Junji
  • KAGEYAMA Tatsuto
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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