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MARKER FOR PANCREATIC CANCER AND INTRADUCTAL PAPILLARY MUCINOUS TUMORS UPDATE

外国特許コード F180009327
整理番号 S2016-0166-C0
掲載日 2018年1月24日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP084537
国際公開番号 WO 2017098915
国際出願日 平成28年11月22日(2016.11.22)
国際公開日 平成29年6月15日(2017.6.15)
優先権データ
  • 特願2015-242679 (2015.12.11) JP
発明の名称 (英語) MARKER FOR PANCREATIC CANCER AND INTRADUCTAL PAPILLARY MUCINOUS TUMORS UPDATE
発明の概要(英語) The purpose of the present invention is to provide a marker that indicates pancreatic cancer and intraductal papillary mucinous tumors, with high sensitivity and specificity. Furthermore, the purpose of the present invention is also to provide a diagnostic kit for pancreatic cancer and intraductal papillary mucinous tumors, which detects this marker, and a method for evaluating metastatic pancreatic cancer and intraductal papillary mucinous tumors, using the marker. This marker of pancreatic cancer and intraductal papillary mucinous tumors is characterized by including one or more proteins, selected from the group consisting of secretoglobin family-1D member 2, and podocalyxin-like protein. Furthermore, this diagnostic kit for pancreatic cancer and intraductal papillary mucinous tumors is characterized by including an antibody for one or more proteins selected from the group consisting of secretoglobin family-1D member 2, and podocalyxin-like protein.
従来技術、競合技術の概要(英語) BACKGROUND ART
'Tumor' refers to an abnormally proliferating cell is, the cause of the abnormal proliferation of the lost or removed to a state in which the duration of cell growth. Benign tumors among the tumor is delayed tumor growth, metastasis is not. Therefore, there is no problem if the cut-in general, even if without cutting through the left to stand in a different situation may be said that the life is not. On the other hand, malignant tumor, the cancer is that, unlike benign tumors and rapidly proliferating on, lymph nodes or other organs via the transition and grow. Thus, for example be removed by surgery, or even a slight remaining cancer cells, metastasized lymph nodes or other organs already has been that a cancer cell can initiate proliferation again. Therefore, after the completion of the once treatment of the cancer is poor prognosis and, in that the survival rate 5 years after each cancer investigation, in general, a cancer treatment from 5 was eliminated when a relapse until after more than one year not considered resolved only.
Pancreatic cancer is, most of cancer is called a poor prognosis. As its causes, the pancreas is retroperitoneal organ is difficult to detect early because as well, for pancreatic cancer cell motility is extremely high, for example even cancers equal to or less than 2cm, the surrounding blood vessel, gastrointestinal tract, such as nerve immediately transfers the infiltration and, further, to nearby lymph nodes or metastatic, or distant metastases to the liver and the like. Therefore, evaluate the progression of the cancer is pancreatic cancer is very important.
Biopsy to diagnose cancer accurate, pain to the patient's biopsy. Thus in general, a cancer marker was used a preliminary inspection is performed. Cancer marker, cancer in vivo by specifically substances produced and, in the fluids in the progression of cancer by measuring the amount can be evaluated. Pancreatic cancer markers include for example, about 30 years before cancer cells specifically expressed in abnormal sugar chains of which CA19-9, yet over CA19-9 pancreatic cancer marker is not put to practical use.
However, particularly early in the diagnosis of cancer is pancreatic cancer CA19-9 poor sensitivity, a problem may be less useful. Therefore, a search of a more excellent than that of the cancer marker. Patent Document 1 is for example, cancer is pancreatic cancer specific protein marker is disclosed.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KOCHI UNIVERSITY
  • 発明者(英語)
  • TANIUCHI, Keisuke
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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