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MARKER FOR PANCREATIC CANCER AND INTRADUCTAL PAPILLARY MUCINOUS TUMORS NEW

外国特許コード F180009327
整理番号 S2016-0166-C0
掲載日 2018年1月24日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP084537
国際公開番号 WO 2017098915
国際出願日 平成28年11月22日(2016.11.22)
国際公開日 平成29年6月15日(2017.6.15)
優先権データ
  • 特願2015-242679 (2015.12.11) JP
発明の名称 (英語) MARKER FOR PANCREATIC CANCER AND INTRADUCTAL PAPILLARY MUCINOUS TUMORS NEW
発明の概要(英語) The purpose of the present invention is to provide a marker that indicates pancreatic cancer and intraductal papillary mucinous tumors, with high sensitivity and specificity. Furthermore, the purpose of the present invention is also to provide a diagnostic kit for pancreatic cancer and intraductal papillary mucinous tumors, which detects this marker, and a method for evaluating metastatic pancreatic cancer and intraductal papillary mucinous tumors, using the marker. This marker of pancreatic cancer and intraductal papillary mucinous tumors is characterized by including one or more proteins, selected from the group consisting of secretoglobin family-1D member 2, and podocalyxin-like protein. Furthermore, this diagnostic kit for pancreatic cancer and intraductal papillary mucinous tumors is characterized by including an antibody for one or more proteins selected from the group consisting of secretoglobin family-1D member 2, and podocalyxin-like protein.
特許請求の範囲(英語) [claim1]
1. Secretase to globin, family 1D, member 2 and is selected from the group consisting PODXL-like protein 1 and protein characterized in that it comprises one or more of the cancer is pancreatic cancer and tumors of the marker in the mucus Hirahata nipple.
[claim2]
2. The secretase to globin, family 1D, member 2 which, following (1) any of the amino acid sequence according to claim 1 - (3) pancreatic cancer and tumors of the marker in the mucus Hirahata nipple. (1) Amino acid sequence SEQ ID NO:1 to 1 amino acid sequence of SEQ ID NO ; (2) 1 or more, the following 5 amino acid deletion, substitution and/or additions to the amino acid sequence having an amino acid sequence SEQ ID NO:1 ; (3) 95% amino acid sequence having a homology of at least.
[claim3]
3. The above-mentioned PODXL-like protein, of any one of the following (4) amino acid sequence according to claim 1 or 2 - (6) pancreatic cancer and tumors of the marker in the mucus Hirahata nipple. (4) Amino acid sequence SEQ ID NO:2 to 2 amino acid sequence of SEQ ID NO ; (5) 1 or more, the following 25 amino acid deletion, substitution and/or additions to the amino acid sequence having an amino acid sequence SEQ ID NO:2 ; (6) 95% amino acid sequence having a homology of at least.
[claim4]
4. Further, any one of the claims 1-3 CA19-9 comprises pancreatic cancer is pancreatic cancer and the tumor marker for papillary mucus.
[claim5]
5. Secretase to globin, family 1D, member 2 and is selected from the group consisting PODXL-like protein 1 comprises one or more antibodies against a protein and the cancer is pancreatic cancer and tumors of the diagnostic kit in the nipple aquiform Hirahata.
[claim6]
6. Further, comprising antibodies according to claim 5 CA19-9 Hirahata nipple cancer is pancreatic cancer and tumors of the diagnostic kit in the mucus.
[claim7]
7. For the evaluation of the cancer is pancreatic cancer cell metastasis method, secretase to globin, family 1D, member 2 and is selected from the group consisting PODXL-like protein by 1 protein in the sample of one or more comprising the steps of measuring the concentration of said method.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KOCHI UNIVERSITY
  • 発明者(英語)
  • TANIUCHI KEISUKE
国際特許分類(IPC)
指定国 (WO201798915)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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