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NOVEL RADIOPROTECTANT

Foreign code F180009354
File No. (S2016-0913-N0)
Posted date Apr 19, 2018
Country WIPO
International application number 2017JP026101
International publication number WO 2018016523
Date of international filing Jul 19, 2017
Date of international publication Jan 25, 2018
Priority data
  • P2016-142646 (Jul 20, 2016) JP
Title NOVEL RADIOPROTECTANT
Abstract Provided is a novel radioprotectant that comprises a compound represented by formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient [in formula (I): a ring A represents a fused ring; and R1 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms]. In particular, provided is a radioprotectant that comprises a compound represented by formula (A) or (B) as an active ingredient. The radioprotectant according to the present invention reduces cell damage and cell death caused by radiation exposure and exhibits an effect of protecting immune-related cells.
Scope of claims [claim1]
1. (I) the compound represented by the formula or a pharmaceutically acceptable salt thereof as active ingredient radioprotective agent containing.
(Formulae, ring fused ring Methoxyphenol A, R1represents a hydrogen atom or an alkyl group having a carbon number of 1-6)
[claim2]
2. A ring is a nitrogen-containing a fuzed ring, according to claim 1 agents.
[claim3]
3. A is a ring, a quinoline or indole, according to claim 2 agents.
[claim4]
4. A is a naphthalene ring, according to claim 1 agents.
[claim5]
5. A tetrahydrobenzo thiophene ring in the, according to claim 1 agents.
[claim6]
6. R1is a methyl group, any one of claims 1-5 dosage.
[claim7]
7. (I) the compound represented by the formula, selected from the group consisting of compounds represented by the following, according to claim 1 agents.
[claim8]
8. (I) the compound represented by the formula, selected from the group consisting of compounds represented by the following, according to claim 1 agents.
[claim9]
9. (I) the compound represented by the formula is a compound represented by the following, according to claim 1 agents.
[claim10]
10. After the irradiation of radiation has a protective effect of immune cells, any one of claims 1-9 dosage.
[claim11]
11. After the irradiation of radiation has a protective effect of intestinal cells, any one of claims 1-10 dosage.
[claim12]
12. When the irradiation of radiation, the radiation treatment due FZDlO, claims 10 or 11 agent.
[claim13]
13. The prevention and/or therapeutic radiation damage in, any one of claims 1-12 dosage.
[claim14]
14. Radiation damage and, at the time of treatment of the side effects of radiation in cancer, according to claim 13 agents.
[claim15]
15. (I) the compound represented by the formula or a pharmaceutically acceptable salt thereof as active ingredient containing, for the prevention and/or therapeutic radiation damage. (Formulae, ring fused ring Methoxyphenol A, R1represents a hydrogen atom or an alkyl group having a carbon number of 1-6)
[claim16]
16. Radiation damage, the side effects of radiation in at the time of treatment of cancer, the prevention and/or therapeutic agent according to claim 15.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NAGASAKI UNIVERSITY
  • Inventor
  • UEDA HIROSHI
  • DEGUCHI YUICHI
  • NAGAI JUN
  • MIZUTA SATOSHI
  • SUZUKI KEIJI
  • MATSUSHITA YOSUKE
  • SAKAI YUKI
IPC(International Patent Classification)
Specified countries (WO201816523)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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