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NOVEL RADIOPROTECTANT

外国特許コード F180009354
整理番号 (S2016-0913-N0)
掲載日 2018年4月19日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP026101
国際公開番号 WO 2018016523
国際出願日 平成29年7月19日(2017.7.19)
国際公開日 平成30年1月25日(2018.1.25)
優先権データ
  • 特願2016-142646 (2016.7.20) JP
発明の名称 (英語) NOVEL RADIOPROTECTANT
発明の概要(英語) Provided is a novel radioprotectant that comprises a compound represented by formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient [in formula (I): a ring A represents a fused ring; and R1 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms]. In particular, provided is a radioprotectant that comprises a compound represented by formula (A) or (B) as an active ingredient. The radioprotectant according to the present invention reduces cell damage and cell death caused by radiation exposure and exhibits an effect of protecting immune-related cells.
特許請求の範囲(英語) [claim1]
1. (I) the compound represented by the formula or a pharmaceutically acceptable salt thereof as active ingredient radioprotective agent containing.
(Formulae, ring fused ring Methoxyphenol A, R1represents a hydrogen atom or an alkyl group having a carbon number of 1-6)
[claim2]
2. A ring is a nitrogen-containing a fuzed ring, according to claim 1 agents.
[claim3]
3. A is a ring, a quinoline or indole, according to claim 2 agents.
[claim4]
4. A is a naphthalene ring, according to claim 1 agents.
[claim5]
5. A tetrahydrobenzo thiophene ring in the, according to claim 1 agents.
[claim6]
6. R1is a methyl group, any one of claims 1-5 dosage.
[claim7]
7. (I) the compound represented by the formula, selected from the group consisting of compounds represented by the following, according to claim 1 agents.
[claim8]
8. (I) the compound represented by the formula, selected from the group consisting of compounds represented by the following, according to claim 1 agents.
[claim9]
9. (I) the compound represented by the formula is a compound represented by the following, according to claim 1 agents.
[claim10]
10. After the irradiation of radiation has a protective effect of immune cells, any one of claims 1-9 dosage.
[claim11]
11. After the irradiation of radiation has a protective effect of intestinal cells, any one of claims 1-10 dosage.
[claim12]
12. When the irradiation of radiation, the radiation treatment due FZDlO, claims 10 or 11 agent.
[claim13]
13. The prevention and/or therapeutic radiation damage in, any one of claims 1-12 dosage.
[claim14]
14. Radiation damage and, at the time of treatment of the side effects of radiation in cancer, according to claim 13 agents.
[claim15]
15. (I) the compound represented by the formula or a pharmaceutically acceptable salt thereof as active ingredient containing, for the prevention and/or therapeutic radiation damage. (Formulae, ring fused ring Methoxyphenol A, R1represents a hydrogen atom or an alkyl group having a carbon number of 1-6)
[claim16]
16. Radiation damage, the side effects of radiation in at the time of treatment of cancer, the prevention and/or therapeutic agent according to claim 15.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NAGASAKI UNIVERSITY
  • 発明者(英語)
  • UEDA HIROSHI
  • DEGUCHI YUICHI
  • NAGAI JUN
  • MIZUTA SATOSHI
  • SUZUKI KEIJI
  • MATSUSHITA YOSUKE
  • SAKAI YUKI
国際特許分類(IPC)
指定国 (WO201816523)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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