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COMPOSITE OF UNDIFFERENTIATED OSTEOBLASTS DERIVED FROM ALVEOLAR BONE AND CARRIER FOR UNDIFFERENTIATED OSTEOBLASTS DERIVED FROM ALVEOLAR BONE, AND USE THEREOF

外国特許コード F180009357
整理番号 (S2016-0340-N0)
掲載日 2018年4月19日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP001827
国際公開番号 WO 2017126638
国際出願日 平成29年1月19日(2017.1.19)
国際公開日 平成29年7月27日(2017.7.27)
優先権データ
  • 特願2016-008352 (2016.1.19) JP
発明の名称 (英語) COMPOSITE OF UNDIFFERENTIATED OSTEOBLASTS DERIVED FROM ALVEOLAR BONE AND CARRIER FOR UNDIFFERENTIATED OSTEOBLASTS DERIVED FROM ALVEOLAR BONE, AND USE THEREOF
発明の概要(英語) The main purpose of the invention is to provide a composite or the like of undifferentiated osteoblasts derived from alveolar bone and a carrier useful in bone tissue regeneration in which undifferentiated osteoblasts derived from alveolar bone are used. A composite of a carried and undifferentiated osteoblasts derived from alveolar bone, wherein the carrier is a fiber molded article having a three-dimensional network structure, the bulk density of the fiber molded article is 0.0001-0.25 g/cm3, and the fibers that constitute the fiber molded article include a biocompatible polymer.
特許請求の範囲(英語) [claim1]
1. An alveolar bone-derived undifferentiated osteoblasts is used as a carrier a composite of: wherein, 3 is attached to the carrier fibers having a three-dimensional network structure is a molded product, and wherein said fiber further 0.0001-0.25 g/cm of the molded product has a density bulky3and, wherein the fiber of the fiber constituting the molded product is a bio-compatible polymer.
[claim2]
2. Wherein the fibers constituting the fiber forming mixture, the biocompatible polymer comprises a hydrophobic, a complex according to claim 1.
[claim3]
3. Wherein the fiber constituting the fiber article, a biocompatible hydrophobic polymer and a biocompatible hydrophilic polymer comprises a composite fiber containing, as described in any one of claims 1 or 2 composite.
[claim4]
4. And wherein the composite fiber, of which the interior of the hydrophobic polymer of a hydrophilic polymer having a structure formed on the fibers, the composite according to claim 3.
[claim5]
5. Wherein the hydrophilic polymer in the fibers of the three-dimensional network structure the inside of the composite fiber to form a 3, of the hydrophilic polymer are bonded to each other by the fibers, the composite fiber structure is formed on a composite fiber twist in contact with each other in control, according to claim 4 composite.
[claim6]
6. Wherein the fiber has a coating layer on at least a part of the moulding composition, of a complex of any one of claims 1-5.
[claim7]
7. Wherein the thickness of the covering layer is 1000μm or less, according to claim 6 composite.
[claim8]
8. An average pore diameter is 10μm or more of the covering layer is comprises a plurality of through holes, according to claim 6 or 7 composite.
[claim9]
9. Wherein the plurality of through holes formed in the area of the opening, the coating layer of the surface area of greater than or equal to 50%, a complex according to claim 8.
[claim10]
10. Wherein the thickness of the carrier is a 0.05-500 mm, a complex of any one of claims 1-9.
[claim11]
11. Wherein the alveolar bone-derived undifferentiated osteoblasts derived from alveolar bone at least a part of the state of being differentiated into osteoblasts, composite of any one of claims 1-10.
[claim12]
12. Wherein the alveolar bone-derived undifferentiated osteoblasts are mineralized state at least in part, any composite of claims 1-10.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOHOKU UNIVERSITY
  • NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
  • 発明者(英語)
  • SAITO MASAHIRO
  • HANDA KEISUKE
  • INAGAKI MASAHIKO
  • KITAGAWA AKIRA
国際特許分類(IPC)
指定国 (WO2017126638)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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