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PHOSPHA-RHODAMINE COMPOUND OR SALT THEREOF, AND FLUORESCENT DYE USING SAME

外国特許コード F180009366
整理番号 (S2016-1019-N0)
掲載日 2018年4月19日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP031203
国際公開番号 WO 2018043579
国際出願日 平成29年8月30日(2017.8.30)
国際公開日 平成30年3月8日(2018.3.8)
優先権データ
  • 特願2016-168882 (2016.8.31) JP
発明の名称 (英語) PHOSPHA-RHODAMINE COMPOUND OR SALT THEREOF, AND FLUORESCENT DYE USING SAME
発明の概要(英語) A phospha-rhodamine compound represented by general formula (1) (in the formula, R1 to R4 are the same or different and each represent a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted (hetero)aryl group; R5 represents a substituted or unsubstituted aryl group; R6 and R7 represent a hydrogen atom; R1 and R6 may be bonded to each other to form a substituted or unsubstituted alkylene group, and/or R3 and R7 may be bonded to each other to form a substituted or unsubstituted alkylene group; R8 represents a substituted or unsubstituted aryl group; and X represents a counterion) or salt thereof can provide a maximum fluorescence wavelength at a longer wavelength than conventional near-infrared fluorescent dyes and can do so without extending the conjugated system of the phospha-rhodamine skeleton.
特許請求の範囲(英語) [claim1]
1. General formula (1) :
formulae, R1-R4are identical or different, a hydrogen atom, substituted or unsubstituted alkyl group, or substituted or unsubstituted (hetero) aryl groups. R5is substituted or unsubstituted aryl group. R6and R7represents a hydrogen atom. R1and R6, and/or R3R and7is, bonded to each other to form a substituted or unsubstituted alkylene group may be used. R8is substituted or unsubstituted aryl group. X is a counter ion. Phospharodamine represented by the compound or salt thereof.
[claim2]
2. R The6and R7are both hydrogen atoms, the compound or salt thereof according to claim 1 phospharodamine.
[claim3]
3. R The6is, in the general formula (2) :formulae, R9and R10are identical or different, a hydrogen atom, substituted or unsubstituted alkyl group, or substituted or unsubstituted alkoxy group. R11is preferably a hydrogen atom or a reactive group. Represented in, according to claim 1 or 2 phospharodamine compound or a salt thereof.
[claim4]
4. R The9and R10if none of the substituted or unsubstituted alkyl group, or substituted or unsubstituted alkoxy group, a compound or salt thereof according to claim 3 phospharodamine.
[claim5]
5. R The11is, with an amine reactive groups or the thiol-reactive group, a compound or salt thereof according to claim 3 or 4 phospharodamine.
[claim6]
6. Wherein the reactive group is a thiol or an amine reactive group, represented by the general formula (3A) -(3E) :formulae, R12represents a hydrogen atom or a sulfo group. R13is substituted or unsubstituted alkyl group. Is the combined solid and dotted lines, a single bond or double bond. A terminal structure represented by the group, according to claim 5 phospharodamine compound or a salt thereof.
[claim7]
7. Any of the claims 1-6 phospharodamine fluorescent dye compound or salt thereof.
[claim8]
8. The compound or salt thereof according to claim 5 or 6 phospharodamine protein using a labeling agent.
[claim9]
9. And a labeling agent according to claim 8 containing protein, a protein labeling kit.
[claim10]
10. And a labeling agent according to claim 8 protein, comprising the steps of reacting a protein, a protein labeling method.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NAGOYA UNIVERSITY
  • 発明者(英語)
  • YAMAGUCHI SHIGEHIRO
  • TAKI MASAYASU
  • SATO YOSHIKATSU
  • NAKA AIKO
  • GRZYBOWSKI MAREK GRZEGORZ
国際特許分類(IPC)
指定国 (WO201843579)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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