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CELL PREPARATION AND METHOD FOR PRODUCING CELL PREPARATION

外国特許コード F180009388
整理番号 (S2016-0900-N0)
掲載日 2018年4月20日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP031246
国際公開番号 WO 2018043596
国際出願日 平成29年8月30日(2017.8.30)
国際公開日 平成30年3月8日(2018.3.8)
優先権データ
  • 特願2016-168543 (2016.8.30) JP
発明の名称 (英語) CELL PREPARATION AND METHOD FOR PRODUCING CELL PREPARATION
発明の概要(英語) The present invention provides: a method for producing a cell culture for the promotion of angiogenesis or the promotion of axonal outgrowth, particularly the treatment of a cerebrovascular disorder, an ischemic heart disease or a traumatic encephalomyeloneuropathy, said method comprising culturing cells including microglial cells and/or monocytes under low oxygen concentration and/or low sugar concentration conditions to produce the culture; a cell preparation produced by the method; and a method for treating a cerebrovascular disorder, an ischemic heart disease or a traumatic encephalomyeloneuropathy using the cell preparation.
特許請求の範囲(英語) [claim1]
1. Promote angiogenesis or axonal extension for the promotion of a method of manufacturing a cell culture, microgial and/or monocytes population in a cell comprising, in which the sugar concentration of the low-oxygen concentration and/or low and culturing under conditions to produce said culture, method.
[claim2]
2. Wherein said culture cerebrovascular, ischemic heart disease or traumatic brain spinal cord for the treatment of neurological disorders, method according to claim 1.
[claim3]
3. Wherein the group of cells including the betaemitting, peripheral blood cell or cell fraction, a method of manufacturing a cell preparation according to claim 1 or 2.
[claim4]
4. Wherein the group of cells including the betaemitting, peripheral blood mononuclear cells collected from a fraction of, of the method according to any one of claims 1-3 1.
[claim5]
5. A low-oxygen concentration, oxygen concentration is less than 1%, 1 according to the method of any one of claims 1-4.
[claim6]
6. In which the sugar concentration is low, in which the sugar concentration is 1.0 g/l or less, wherein the method of any one of claims 1-5 1.
[claim7]
7. Wherein the group of cells is a low oxygen concentration and low sugar concentration culturing under conditions of less than 24, wherein the method of any one of claims 1-6 1.
[claim8]
8. After cleaning said culture, further comprising container, wherein the method of any one of claims 1-7 1.
[claim9]
9. Cerbrovascular, ischemic heart disease treatment of neurological disorders or traumatic spinal cord sufficient antineovascularization promotion and/or axonal extension capable of stimulating and/or a single sphere microgial having, cerebrovascular disorders, ischemic heart disease or traumatic brain arachnoidea Neuronopathies formulation for the treatment of the cells.
[claim10]
10. 1 The method of any one of claims 1-8 generated by including a culture, a cell preparation according to claim 9.
[claim11]
11. 1 The method of any one of claims 1-8 generated by the culture, promote angiogenesis axon or a cell preparation for the promotion of extension.
[claim12]
12. Microgial and/or monocytes population in a cell comprising, in which the sugar concentration of the low-oxygen concentration and/or low and culturing under conditions generated by, a therapeutically effective amount of microgial and/or monocytes and culture, comprising administering to the subject, cerebrovascular disorders, ischemic heart disease or a disorder traumatic brain and spinal neurons.
[claim13]
13. The cerebral vascular disease, ischemic heart disease or traumatic brain and spinal neurons for use in the treatment of the disorder, the low-oxygen concentration and/or low in which the sugar concentration microgial cultureware with conditions and/or monocytes.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NIIGATA UNIVERSITY
  • 発明者(英語)
  • SHIMOHATA TAKAYOSHI
  • KANAZAWA MASATO
国際特許分類(IPC)
指定国 (WO201843596)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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