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CELL PREPARATION AND METHOD FOR PRODUCING CELL PREPARATION

外国特許コード F180009388
整理番号 (S2016-0900-N0)
掲載日 2018年4月20日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP031246
国際公開番号 WO 2018043596
国際出願日 平成29年8月30日(2017.8.30)
国際公開日 平成30年3月8日(2018.3.8)
優先権データ
  • 特願2016-168543 (2016.8.30) JP
発明の名称 (英語) CELL PREPARATION AND METHOD FOR PRODUCING CELL PREPARATION
発明の概要(英語) The present invention provides: a method for producing a cell culture for the promotion of angiogenesis or the promotion of axonal outgrowth, particularly the treatment of a cerebrovascular disorder, an ischemic heart disease or a traumatic encephalomyeloneuropathy, said method comprising culturing cells including microglial cells and/or monocytes under low oxygen concentration and/or low sugar concentration conditions to produce the culture; a cell preparation produced by the method; and a method for treating a cerebrovascular disorder, an ischemic heart disease or a traumatic encephalomyeloneuropathy using the cell preparation.
従来技術、競合技術の概要(英語) BACKGROUND ART
Brain infarction, ischemic necrosis of the brain regional brain function caused by the failure point, the necessary care and disease, cancer and heart disease and 3 are arranged in one of the major causes. Cerebral infarcts, from the viewpoint of the mechanism of action, thrombotic, embolic, hemodynamic property is classified into, from side surfaces of the clinical findings aiding in the cerebral infarction, cardiogenic cerebral embolism, lacunar infarction such as classifications.
Ischemia, cerebral vascular lesions such as arteriosclerosis, thrombus or cardiogenic local cerebral blood flow is blocked by us, in a central portion of the ischemic neuronal cell death is caused due to energy depletion. After ischemia, poor nerve regeneration, chronic symptoms is difficult for the current recovery, there is a possibility that some sequelae half. Ischemia the center of the side edge part of the nerve regeneration as processes, and triggers that revascularization is assumed. As the target which has been desired the development of therapeutics.
For the treatment of cerebral infarction have been various attempts have been made, is not sufficient, in recent years methods of treatment using a living cell has been attempted (Patent Document 1 and 2, see Non Patent Literature 1).
Patent Document 1 is, taken from the blood or bone marrow mesenchymal stem cells to the cells, without using an anticoagulant such as heparin was taken, using the method for treating a disease such as cerebral infarction has been described. Patent Document 2 is, for the treatment of cerebral infarction using MUSE cells and a method.
In addition, bone marrow-derived monocytes mouse cerebral infarction model (CD115 - positive cells) can be administered intravenously, infarcted and proceeds to present cells, the effect is confirmed, the effect is not sufficient (see Non-Patent Document 1).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NIIGATA UNIVERSITY
  • 発明者(英語)
  • SHIMOHATA, Takayoshi
  • KANAZAWA, Masato
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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