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THERAPEUTIC AGENT FOR PERIODONTITIS AND COMPOSITION FOR TREATING PERIODONTITIS

Foreign code F180009393
File No. (12048)
Posted date Apr 20, 2018
Country WIPO
International application number 2017JP026481
International publication number WO 2018021188
Date of international filing Jul 21, 2017
Date of international publication Feb 1, 2018
Priority data
  • P2016-146593 (Jul 26, 2016) JP
Title THERAPEUTIC AGENT FOR PERIODONTITIS AND COMPOSITION FOR TREATING PERIODONTITIS
Abstract Provided is a therapeutic agent for periodontitis containing a Hepatocyte Growth Factor (HGF) signal inhibitor as an active ingredient.
Outline of related art and contending technology BACKGROUND ART
Of an adult and the interrupt 8 is suffering from the disease, gingivitis and periodontitis are divided into. Gingivitis is due to bacterial diseases and, can be treated. On the other hand, the final teeth periodontitis disease and falls off, effective therapy has not been established.
Conventional, oral periodontatitis is an infection by a resident is considered, the treatment is continued to remove the bacteria have been. However, the extraction of about 40% due to periodontitis, periodontitis to overcome long journey is still left (for example, see Non-Patent Document 1).
However, support the protein collagen tissue, living tissue such as skin and bone to play an important role in the formation. Collagen, periodontal tissue and may be involved in the formation of the, inflammation of the gingiva and the periodontal ligament tissue destroyed by collagen, and the alveolar bone and connective tissue-tooth loss of adhesion, the shedding takes place of the teeth. Before the inventors of the invention, periodontal tissue in vivo degradation of collagen in a condition close to, in vitro can be evaluated in a three-dimensional culture system (see Patent Document 1) was developed.
Scope of claims (In Japanese)[請求項1]
肝細胞増殖因子(HGF)シグナル阻害剤を有効成分として含有する歯周炎治療薬。
[請求項2]
前記HGFシグナル阻害剤が、HGF特異的結合物質、HGF発現阻害剤、HGF活性化酵素特異的結合物質、HGF活性化酵素発現阻害剤、HGF活性化酵素阻害剤、c-Met特異的結合物質、c-Met発現阻害剤及びc-Met阻害剤からなる群より選択される、請求項1に記載の歯周炎治療薬。
[請求項3]
請求項1又は2に記載の歯周炎治療薬及び薬学的に許容可能な担体を含む歯周炎治療用組成物。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NIHON UNIVERSITY
  • Inventor
  • YAMAGUCHI Yoko
  • OHSHIMA Mitsuhiro
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
Reference ( R and D project ) NIHON UNIVERSITY's Researcher Information
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