TOP > 外国特許検索 > METHOD AND TEST PIECE FOR TESTING FOR KAWASAKI DISEASE

METHOD AND TEST PIECE FOR TESTING FOR KAWASAKI DISEASE

外国特許コード F180009396
整理番号 (S2016-1017-N0)
掲載日 2018年4月20日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP028236
国際公開番号 WO 2018030270
国際出願日 平成29年8月3日(2017.8.3)
国際公開日 平成30年2月15日(2018.2.15)
優先権データ
  • 特願2016-156241 (2016.8.9) JP
発明の名称 (英語) METHOD AND TEST PIECE FOR TESTING FOR KAWASAKI DISEASE
発明の概要(英語) To provide a method and test piece for quickly and easily testing for Kawasaki disease. A method for testing for Kawasaki disease characterized by measuring the levels of lipopolysaccharide-binding protien (LBP) and leucine-rich α2-glycoprotien (LRG1) in a sample originating from a subject to be tested. A test piece for detecting Kawasaki disease through an immunochromatography method, the test piece containing carriers on which anti-LBP antibodies are fixed, and carriers on which anti-LRG1 antibodies are fixed.
従来技術、競合技術の概要(英語) BACKGROUND ART
4 Years old or younger infants kawasaki disease is mainly found in acute febrile rash and disease, systemic vasculitis in the main body of the condition. Kawasaki disease diagnosis of symptoms of the plurality of primary (1. 5 or more subsequent heating, 2. on both sides of the bulbar conjunctiva of the congestion, 3. lip redness, concentrate the tongue, 4. of the irregular shaped rash, 5. acute phase of the hand fingers of the rigid, hand palms and soles erythema, antipyretic of the film-like desquamation, purulent lymphadenopathy non-of the neck 6.) performed by the appearance of (kawasaki disease diagnosis guidance). In the blood, white blood cell count, C-reactive protein, without departing from the increase of the enzyme in the liver cells, enhancement of erythrocyte sedimentation, such as white blood cells (neutrophils ratio) the fractions is checked, two-dimensional echocardiography or cardiovascular imaging method such as a check of coronary lesions has also been performed.
Kawasaki disease is a disease in a natural a sophisticated, non-treatment of after the elapse of the 25-30% coronary lesions in the patient's cardiac complications typically occur. Therefore, in developing a treatment was initiated early kawasaki disease, inflammation and sedation is important, and have even 1 heat period can be shortened, it is possible to prevent the occurrence of complications of the heart is needed. However, the mechanism of the development and pathogenesis kawasaki disease is not known yet and, instead of the specific diagnostic tests, and for the major symptoms of the individual difference, there are a multitude of example does not meet the diagnostic criteria. Therefore, rapid definitive diagnosis is difficult kawasaki disease.
In addition, the diagnosis of patents kawasaki disease, blood of VEGF (Vascular Endothelial Growth Factor: vascular endothelial growth factor) a method of measuring concentration (Patent Document 1: JP-11-6832), 1 or IgM antigen a method of measuring a plurality of super (Patent Document 2: JP-3-139294), other, the investigation of genetic polymorphism (Patent Document 3: JP-2009-72193) and the like, a clinical site is actually not yet been used.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • YOKOHAMA CITY UNIVERSITY
  • 発明者(英語)
  • HORIUCHI, Yayoi
  • MORI, Masaaki
  • HIRANO, Hisashi
  • SAITO, Yoko
国際特許分類(IPC)
※ ライセンスをご希望の方、特許の内容に興味を持たれた方は、問合せボタンを押してください。

PAGE TOP

close
close
close
close
close
close