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Substance-encapsulating vesicle and process for producing the same

外国特許コード F180009411
整理番号 AF12-07US2
掲載日 2018年4月20日
出願国 アメリカ合衆国
出願番号 201715660746
公報番号 20180015036
出願日 平成29年7月26日(2017.7.26)
公報発行日 平成30年1月18日(2018.1.18)
国際出願番号 JP2011061790
国際公開番号 WO2011145745
国際出願日 平成23年5月23日(2011.5.23)
国際公開日 平成23年11月24日(2011.11.24)
優先権データ
  • 特願2010-117821 (2010.5.21) JP
  • 特願2010-117823 (2010.5.21) JP
  • 2011WO-JP61790 (2011.5.23) WO
  • 2012US-13699238 (2012.11.20) US
発明の名称 (英語) Substance-encapsulating vesicle and process for producing the same
発明の概要(英語) (US20180015036)
Provided is a method for easily and efficiently producing encapsulated substance vesicles wherein a substance is encapsulated in the cavity of vesicles obtained by polymer self-assembly.
Empty vesicles that have membranes comprising a first polymer that is a block copolymer with uncharged hydrophilic segments and a first kind of charged segments and a second polymer with a second kind of charged segments that carry a charge that is the opposite of said first kind of charged segments as well as spaces that are enclosed by said membranes are mixed in an aqueous medium with the substance that is to be encapsulated in the spaces.
特許請求の範囲(英語) [claim1]
1. A vesicle comprising a membrane containing: a block copolymer having an uncharged hydrophilic segment and a cationic segment; and a nucleic acid; said membrane defining a cavity surrounded thereby.
[claim2]
2. A vesicle according to claim 1, wherein the membrane has a trilaminar structure comprising an outer layer, an intermediate layer, and an inner layer.
[claim3]
3. A vesicle according to claim 1, which has an N+/P ratio of higher than 1.0 and lower than 3.0, the N+/P ratio being a mole ratio of cationic groups of the cationic segment to phosphate groups of the nucleic acid.
[claim4]
4. A vesicle according to claim 1, wherein the uncharged hydrophilic segment is polyalkylene glycol.
[claim5]
5. A vesicle according to claim 1, wherein the cationic segment is polyamine.
[claim6]
6. A vesicle according to claim 1, wherein the membrane further comprises a cross-linker.
[claim7]
7. A vesicle according to claim 6, which has a CL/N ratio of 0.1 or higher, the CL/N ratio being a mole ratio of the cross-linker to cationic groups of the cationic segment.
[claim8]
8. A vesicle according to claim 6, wherein the cross-linker is glutaraldehyde.
[claim9]
9. A vesicle according to claim 1, for use in a drug delivery system.
[claim10]
10. A drug delivery system comprising a vesicle having a membrane containing: a block copolymer having an uncharged hydrophilic segment and a cationic segment, said membrane defining a cavity surrounded thereby; and a charged substance encapsulated in the cavity.
  • 発明者/出願人(英語)
  • KATAOKA KAZUNORI
  • KISHIMURA AKIHIRO
  • ANRAKU YASUTAKA
  • MIYATA KANJIRO
  • CHUANOI SAYAN
  • SUMA TOMOYA
  • OBA MAKOTO
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
参考情報 (研究プロジェクト等) CREST Establishment of Innovative Manufacturing Technology Based on Nanoscience AREA
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