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Substance-containing vesicle, and production method therefor

Foreign code F180009414
File No. AF12-14US2
Posted date Apr 20, 2018
Country United States of America
Application number 201715683988
Gazette No. 20180008549
Date of filing Aug 23, 2017
Gazette Date Jan 11, 2018
International application number JP2014055186
International publication number WO2014133172
Date of international filing Feb 28, 2014
Date of international publication Sep 4, 2014
Priority data
  • P2013-041186 (Mar 1, 2013) JP
  • P2013-176068 (Aug 27, 2013) JP
  • 2014WO-JP55186 (Feb 28, 2014) WO
  • 2015US-14839854 (Aug 28, 2015) US
Title Substance-containing vesicle, and production method therefor
Abstract (US20180008549)
Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible.
A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked.
As a result, the crosslinked vesicle is made to contain the target substance.
Scope of claims [claim1]
1. An adsorbent-encapsulating vesicle comprising: a vesicle composed of a membrane comprising a first polymer, which is block copolymer having an uncharged hydrophilic segment and a first charged segment, and a second polymer, which has a second charged segment having a charge opposite to the charge of the first charged segment; and
an adsorbent particle encapsulated in the vesicle,
wherein at least either the first polymer or the second polymer is adsorbed by the adsorbent particle.
[claim2]
2. The adsorbent-encapsulating vesicle according to claim 1, wherein the first and/or second polymer(s) is(are) crosslinked.
[claim3]
3. The adsorbent-encapsulating vesicle according to claim 1, wherein the adsorbent particle is a silica particle.
[claim4]
4. The adsorbent-encapsulating vesicle according to claim 1, wherein the adsorbent particle has an average particle size of between 40 nm and 10 mu m.
[claim5]
5. The adsorbent-encapsulating vesicle according to claim 1, wherein the adsorbent particle has been surface-treated.
[claim6]
6. The adsorbent-encapsulating vesicle according to claim 1, wherein a low-molecular compound is adsorbed by the adsorbent particle.
[claim7]
7. A method of producing the adsorbent-encapsulating vesicle of claim 1, said method comprising the steps of: (a) mixing one of the first and second polymers with the adsorbent particle to have the one of the first and second polymers adsorbed by the adsorbent particle; and
(b) further mixing the mixture from step (a) with the other of the first and second polymers to form a vesicle composed of a membrane comprising the first and second polymers around the adsorbent particle, thereby forming the adsorbent-encapsulating vesicle.
[claim8]
8. The method according to claim 7, further comprising: (c) crosslinking the first and/or the second polymer(s) contained in the vesicle from step (b).
[claim9]
9. The method according to claim 7, wherein the adsorbent particle is a silica particle.
[claim10]
10. The method according to claim 7, wherein the adsorbent particle has an average particle size between 40 nm and 10 mu m.
[claim11]
11. The method according to claim 7, further comprising a step of surface-treating the adsorbent particle.
[claim12]
12. The method according to claim 7, wherein a low-molecular compound is adsorbed by the adsorbent particle.
[claim13]
13. A drug delivery system comprising the adsorbent-encapsulating vesicle according to claim 1.
  • Inventor, and Inventor/Applicant
  • KATAOKA KAZUNORI
  • KISHIMURA AKIHIRO
  • ANRAKU YASUTAKA
  • GOTO AKINORI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
IPC(International Patent Classification)
Reference ( R and D project ) CREST Establishment of Innovative Manufacturing Technology Based on Nanoscience AREA
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