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Substance-containing vesicle, and production method therefor

外国特許コード F180009414
整理番号 AF12-14US2
掲載日 2018年4月20日
出願国 アメリカ合衆国
出願番号 201715683988
公報番号 20180008549
出願日 平成29年8月23日(2017.8.23)
公報発行日 平成30年1月11日(2018.1.11)
国際出願番号 JP2014055186
国際公開番号 WO2014133172
国際出願日 平成26年2月28日(2014.2.28)
国際公開日 平成26年9月4日(2014.9.4)
優先権データ
  • 特願2013-041186 (2013.3.1) JP
  • 特願2013-176068 (2013.8.27) JP
  • 2014WO-JP55186 (2014.2.28) WO
  • 2015US-14839854 (2015.8.28) US
発明の名称 (英語) Substance-containing vesicle, and production method therefor
発明の概要(英語) (US20180008549)
Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible.
A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked.
As a result, the crosslinked vesicle is made to contain the target substance.
特許請求の範囲(英語) [claim1]
1. An adsorbent-encapsulating vesicle comprising: a vesicle composed of a membrane comprising a first polymer, which is block copolymer having an uncharged hydrophilic segment and a first charged segment, and a second polymer, which has a second charged segment having a charge opposite to the charge of the first charged segment; and
an adsorbent particle encapsulated in the vesicle,
wherein at least either the first polymer or the second polymer is adsorbed by the adsorbent particle.
[claim2]
2. The adsorbent-encapsulating vesicle according to claim 1, wherein the first and/or second polymer(s) is(are) crosslinked.
[claim3]
3. The adsorbent-encapsulating vesicle according to claim 1, wherein the adsorbent particle is a silica particle.
[claim4]
4. The adsorbent-encapsulating vesicle according to claim 1, wherein the adsorbent particle has an average particle size of between 40 nm and 10 mu m.
[claim5]
5. The adsorbent-encapsulating vesicle according to claim 1, wherein the adsorbent particle has been surface-treated.
[claim6]
6. The adsorbent-encapsulating vesicle according to claim 1, wherein a low-molecular compound is adsorbed by the adsorbent particle.
[claim7]
7. A method of producing the adsorbent-encapsulating vesicle of claim 1, said method comprising the steps of: (a) mixing one of the first and second polymers with the adsorbent particle to have the one of the first and second polymers adsorbed by the adsorbent particle; and
(b) further mixing the mixture from step (a) with the other of the first and second polymers to form a vesicle composed of a membrane comprising the first and second polymers around the adsorbent particle, thereby forming the adsorbent-encapsulating vesicle.
[claim8]
8. The method according to claim 7, further comprising: (c) crosslinking the first and/or the second polymer(s) contained in the vesicle from step (b).
[claim9]
9. The method according to claim 7, wherein the adsorbent particle is a silica particle.
[claim10]
10. The method according to claim 7, wherein the adsorbent particle has an average particle size between 40 nm and 10 mu m.
[claim11]
11. The method according to claim 7, further comprising a step of surface-treating the adsorbent particle.
[claim12]
12. The method according to claim 7, wherein a low-molecular compound is adsorbed by the adsorbent particle.
[claim13]
13. A drug delivery system comprising the adsorbent-encapsulating vesicle according to claim 1.
  • 発明者/出願人(英語)
  • KATAOKA KAZUNORI
  • KISHIMURA AKIHIRO
  • ANRAKU YASUTAKA
  • GOTO AKINORI
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
国際特許分類(IPC)
参考情報 (研究プロジェクト等) CREST Establishment of Innovative Manufacturing Technology Based on Nanoscience AREA
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