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THERAPEUTIC AGENT FOR ADHESION, METHOD FOR TREATING ADHESION, POSTOPERATIVE ADHESION MARKER, AND METHOD FOR EXAMINING SUSCEPTIBILITY TO POSTOPERATIVE ADHESION

外国特許コード F180009421
整理番号 2016-002
掲載日 2018年4月26日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP028869
国際公開番号 WO 2018030451
国際出願日 平成29年8月9日(2017.8.9)
国際公開日 平成30年2月15日(2018.2.15)
優先権データ
  • 特願2016-156962 (2016.8.9) JP
発明の名称 (英語) THERAPEUTIC AGENT FOR ADHESION, METHOD FOR TREATING ADHESION, POSTOPERATIVE ADHESION MARKER, AND METHOD FOR EXAMINING SUSCEPTIBILITY TO POSTOPERATIVE ADHESION
発明の概要(英語) The present invention provides a therapeutic agent for an adhesion, a method for treating an adhesion, a postoperative adhesion marker and a method for testing for susceptibility to a postoperative adhesion, each of which can be applied to an adhesion occurring, for example, during an operation with an endoscope or the like or in an endogenous disease. The therapeutic agent for an adhesion according to the present invention is characterized by containing an expression-inhibiting substance capable of inhibiting the expression of periostin and/or a binding substance capable of binding to periostin. In the therapeutic agent for an adhesion according to the present invention, the expression-inhibiting substance comprises at least one substance selected from the group consisting of a substance capable of inhibiting the expression of mRNA for a periostin gene, a substance capable of cleaving the expressed mRNA and a substance capable of inhibiting the translation of a protein from the expressed mRNA.
従来技術、競合技術の概要(英語) BACKGROUND ART
Laparotomy, thoracotomy, such as endoscopic surgery in the case where the surgery, after surgery, surgery to repair damaged tissue. In this case, prior to the surgery has been spaced apart from each other organs and tissues in contact with the tissue regeneration may occur and, as a result, adhesion may occur. For example, in the case where the surgical laparotomy, in response to a surgery in a patient, adhesion may occur with high probability is known. Then, such adhesion occurs, due to the adhesion of the adherent such as the bowel disease might occur.
For this reason, adhesion caused by the operation, that is, in order to prevent adhesions, the adhesion prevention film such as a sheet-like adhesion prevention material has been commonly used (Patent Document 1 and 2).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • EDUCATIONAL FOUNDATION OF OSAKA MEDICAL AND PHARMACEUTICAL UNIVERSITY
  • AQUA THERAPEUTICS CO., LTD.
  • 発明者(英語)
  • TAKAI Shinji
  • KIN Tokunan
  • YOSHIKAWA Kazunori
  • TAKAO Kazumasa
  • YOSHINO Masafumi
国際特許分類(IPC)

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