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FINE FLUORESCENT PARTICLE CONTAINING AIE-ACTIVE COMPOUND 新技術説明会

外国特許コード F180009437
整理番号 (S2016-1198-N0)
掲載日 2018年7月23日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP034621
国際公開番号 WO 2018056454
国際出願日 平成29年9月26日(2017.9.26)
国際公開日 平成30年3月29日(2018.3.29)
優先権データ
  • 特願2016-186496 (2016.9.26) JP
発明の名称 (英語) FINE FLUORESCENT PARTICLE CONTAINING AIE-ACTIVE COMPOUND 新技術説明会
発明の概要(英語) The purpose of the present invention is to provide a fine fluorescent particle which suffers no concentration quenching and has low ecotoxicity. Specifically, the present invention relates to a fine fluorescent particle comprising a network polymer and containing an AIE-active compound, characterized in that the AIE-active compound is, for example, a compound represented by general formula (1). (In formula (1), E is a silicon or germanium atom, R1 and R2 are the same or different and are each a C1-6 hydrocarbon group or an(un)substituted phenyl group, and R3, R4, R5, and R6 are the same or different and are each an (un)substituted phenyl group.)
従来技術、競合技術の概要(英語) BACKGROUND ART
Fluorescent fine particle, such as an antibody bound to the material in the target recognition, target material can be fluorescently labeled. For example, the surface of a cancer cell specific antibodies that recognize a molecule that binds to a fluorescent fine particle is bonded, this test sample as the probe can determine the presence or absence of cancer cells in the cell, presence or absence of susceptibility to cancer may be diagnosed. In addition, the level of an individual or a cell or tissue distribution of the localization of biomolecules such as proteins bio-imaging in an image, the probe is being used as a fluorescent label. Among these, organic polymer resin is filled with the fluorescent particles of the fluorescent substance, color, size, surface modification of the different products are commercially available and some embodiments, biological, medical and diagnostic research fields such as clinical medicine and its usefulness in the field have been observed (Patent Document 1, Patent Document 2).
Enclosed in the fluorescent particles of the known and many of the fluorescent material, π conjugated system high plane extending a compound, such compound is, a high concentration in an extreme reduction in emission intensity 'concentration quenching' is known to cause. Therefore, the amount of fluorescent material may be encapsulated in a polymer resin is limited, in practice the inventors have found that in a commercially available product has been confirmed that the concentration quenching occurs. When a small amount of labeled target, in order to effectively detect the target, is preferably used for the fluorescent particles as bright as possible, encapsulated in a polymer resin and the fluorescent substance per unit amount of necessary to use a larger number. However, can be enclosed in the resin molecules of the fluorescent material in the prior art since there is a limit to the amount, as long as the conventional fluorescent material is used, the brightness of the fluorescent particles can be produced by limiting.
And the fluorescent particles are used in similar applications is a quantum dot, the quantum dot is cadmium, selenium for use of a highly toxic element, is not suitable for use in in vivo. In addition, the fluorescence yield is not so high and -50%, there is a problem in terms of brightness.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • SAITAMA UNIVERSITY
  • 発明者(英語)
  • HATANO Ken
  • MATSUSHITA Takahiko
  • FUJIKAWA Daisuke
  • MATSUOKA Koji
国際特許分類(IPC)
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