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DISEASE CONDITION DETERMINATION DEVICE, DISEASE CONDITION DETERMINATION SYSTEM, AND DISEASE CONDITION DETERMINATION PROGRAM NEW

外国特許コード F180009441
整理番号 (S2016-1170-N0,12055)
掲載日 2018年7月24日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP033034
国際公開番号 WO 2018056137
国際出願日 平成29年9月13日(2017.9.13)
国際公開日 平成30年3月29日(2018.3.29)
優先権データ
  • 特願2016-183437 (2016.9.20) JP
発明の名称 (英語) DISEASE CONDITION DETERMINATION DEVICE, DISEASE CONDITION DETERMINATION SYSTEM, AND DISEASE CONDITION DETERMINATION PROGRAM NEW
発明の概要(英語) The disease condition determination device according to the present invention is provided with: a first separation degree calculation unit for calculating a degree of separation on the basis of first load blood flow information which is blood flow information for a task state in which a first load for varying the blood flow state of a subject is imposed on the subject, and second load blood flow information which is blood flow information for a control state in which a second load different from the first load is imposed on the subject, from among blood flow information obtained by measuring blood flow in the brain of a subject by optical measurement using near-infrared rays; an oscillation detection unit for detecting oscillation in variation of the hemoglobin concentration of the blood flow of the subject on the basis of non-load blood flow information; a phase detection unit for detecting the phase of the variation in hemoglobin concentration of the blood flow of the subject on the basis of the non-load blood flow information; and a determination unit for determining the disease condition of the subject on the basis of the degree of separation calculated by the first separation degree calculation unit, the oscillation detected by the oscillation detection unit, and the phase detected by the phase detection unit.
特許請求の範囲(英語) [claim1]
1. An optical measurement of the object by using the infrared cerebral blood flow of the measured blood flow information, the subject changes the state of blood flow in a load of the load on the subject with the 1 first tasks of the state of the blood flow information of the first blood flow information and the load 1, wherein the first load is different from the first load 1 2 load given to the subject of the second control state in the blood flow information based on the blood flow information and the load 2, calculating the separation degree calculation unit and the second separation 1, where the load is given to the subject is not in the blood flow information based on the non-load information of a blood flow, blood flow of the subject and the hemoglobin concentration of said change to detect the amplitude of the amplitude detection part and, based on the information of the flow of blood to no load, wherein said blood flow of the subject and the phase of the change in the concentration of hemoglobin and the detection unit for detecting the phase, wherein the first calculation unit which calculates a degree of separation is 1 and a degree of separation, wherein the amplitude detection section detects the amplitude and, according to the phase detection unit detects based on said phase, wherein the determination unit and the condition of the subject, the condition determination device is provided.
[claim2]
2. A near-infrared optical measurement using the blood flow of the brain of the subject is measured one of the blood flow information, the subject changes the state of blood flow in a load of the load on the subject with the 1 first tasks of the state of the blood flow information of the first blood flow information and the load 1, wherein the first load is different from the first 1 serving as a load to the load according to claim 2 provided in the control of the state of the blood flow information based on first blood flow information and the load 2, calculating the separation degree calculation unit and the second separation 1, where the load to the subject has not been provided with the non-load state of the blood flow information based on the blood flow information, and the concentration of hemoglobin in blood flow of the subject to detect the amplitude of the amplitude detection section and changes, 1 wherein the first separation degree calculation unit calculates the degree of separation of the and, wherein the amplitude detection unit detects based on the amplitude, wherein the determination unit and the condition of the subject, a condition determining device.
[claim3]
3. Wherein the amplitude detecting section is, the scatter plot using an area of the detected amplitudes according to claim 2 or claim 1 condition determining device.
[claim4]
4. Using a near-infrared optical measurement blood flow of the brain of the subject measured one of the blood flow information, the flow of blood of the subject and the second load 1 to change the state on the subject with a load of the tasks of the state of blood flow in the blood flow information and the second load information 1, wherein the first load is different from the first 1 according to claim 2 serving as a load that is applied to the load control in a state where the first blood flow information 2 based on the load information of a blood flow, calculating the separation degree calculation unit and the second separation 1, wherein the subject is not the load is applied to the blood flow state of the non-load information based on the blood flow information, and the concentration of hemoglobin in blood flow of the subject and wherein the phase of the phase detection unit and detecting the change, the degree of separation of 1 wherein the first calculating unit calculates the degree in separation, wherein according to the phase detection unit detects based on the phase, wherein the determination unit and the condition of the subject, a condition determining device.
[claim5]
5. Wherein the phase detection unit, detecting a phase by using the Hilbert transformer according to claim 4 or claim 1 condition determining device.
[claim6]
6. 1 The separation degree calculation unit calculates the degree in separation, wherein the task state, the control state is obtained by multiplying the weighting coefficients based on the weighted calculating the separation degree calculation unit further comprises a first separation 2 the determination unit may determine, 2 the degree of separation of the first calculation unit which calculates a degree of separation is further based on the weighted, wherein determining the condition of the subject from any one of claims claim 1 claim 5 pathological condition determining device.
[claim7]
7. Wherein said blood flow information is, the outer portion of the back of the subject and the prefrontal to measure the blood flow information from any one of claims claim 1 in claim 6 pathological condition determining device.
[claim8]
8. 1 The first blood flow information based on the load, and the concentration of hemoglobin in blood flow of the subject to detect the amplitude of a change in the amplitude detection part further comprises a second load 1, the determining unit, wherein the first load 1 detected by the amplitude detection unit in a state where the task based on the amplitude, wherein the determining the condition of the subject, wherein any one of claims from the claim 1 claim 7 pathological condition determining device.
[claim9]
9. Wherein the state of the task, presenting the presentation information stored in a storage state, the storage state based on the presentation information stored in the operation of performing the operation included in the state, wherein the first load amplitude detecting section is 1, the storage state of the data acquisition in first blood flow information based on the load 1, the concentration of hemoglobin in blood flow of the subject and the amplitude of said detected change, the determination unit determines, wherein the first load 1 detected by the amplitude detection unit based on the amplitude in the storage state, wherein determining the condition of the subject, the condition determination device according to claim 8.
[claim10]
10. Wherein the state of the task, presenting the presentation information is stored and a memory state, the presentation information stored in the storage state on the basis of the operation of performing the operation included in the state, wherein the first load and the amplitude detection part is 1, the first working state acquired in the blood flow information based on the load 1, wherein the hemoglobin concentration of the blood flow of the subject and detecting the amplitude of the change, the determination unit may, wherein the first load and the amplitude detection part detected by the position 1 in a state where the operation based on the amplitude, wherein the determining the condition of the subject, according to claim 9 or claim 8 condition determining device.
[claim11]
11. 2 The first blood flow information based on the load, and the concentration of hemoglobin in blood flow of the subject to detect the amplitude of a change in the amplitude detection part further comprises a second load 2, the determination unit may determine, 2 wherein the first load and the amplitude detection part detected by the position control state based on the amplitude in, determining the condition of the subject wherein any one of claims from the claim 1 claim 10 pathological condition determining device.
[claim12]
12. Claim 1 claim 7 from any one of the condition of said apparatus for determining, using a near-infrared optical measurement of the brain of the subject and to measure the blood flow, blood flow information indicative of said blood flow meter outputs, wherein determining when the determination section determines the condition of the subject in the display section for displaying the determination result, determines a system condition.
[claim13]
13. The computer, using a near-infrared optical measurement to measure the blood flow of the brain of the subject and the one of the blood flow information, the subject changes the state of blood flow in a load of the load on the subject with the 1 first tasks of the state of the blood flow information of the first blood flow information and the load 1, wherein the first load is different from the first 1 2 serving as a load where the load has been given to the subject of the second control state in the blood flow information based on the blood flow information and the load 2, calculating the separation and the degree of separation of 1 the first calculation step, the subject has not been provided with the load state of the blood flow information based on the non-load information of a blood flow, and the concentration of hemoglobin in blood flow of the subject and the change in the amplitude of the amplitude detected by the detection step, the blood flow information based on the non-load wherein the concentration of hemoglobin in blood flow of the subject and the change in the detection step for detecting the phase of the phase, wherein the first calculation step which calculates a degree of separation is 1 and a degree of separation, wherein the amplitude detection step of detecting the amplitude and, according to the phase detection step of detecting on the basis of the phase, wherein the determination step and the condition of the subject, the determination of the disease condition for execution of the program.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NIHON UNIVERSITY
  • 発明者(英語)
  • YANAGISAWA KAZUKI
  • TSUNASHIMA HITOSHI
  • NARITA NAOKO
国際特許分類(IPC)
指定国 (WO201856137)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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