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PREVENTIVE AGENT AND THERAPEUTIC AGENT FOR CATARACTS, AND USE OF HAT INHIBITOR FOR PRODUCTION THEREOF

Foreign code F180009453
File No. (FU684)
Posted date Jul 25, 2018
Country WIPO
International application number 2017JP019034
International publication number WO 2018078922
Date of international filing May 22, 2017
Date of international publication May 3, 2018
Priority data
  • P2016-208121 (Oct 24, 2016) JP
Title PREVENTIVE AGENT AND THERAPEUTIC AGENT FOR CATARACTS, AND USE OF HAT INHIBITOR FOR PRODUCTION THEREOF
Abstract Provided are: a novel preventive agent and a novel therapeutic agent for cataracts; and use of an HAT inhibitor for production thereof. The preventive agent or therapeutic agent for cataracts according to the present invention contains an HAT inhibitor as an active ingredient.
Scope of claims [claim1]
1. HAT inhibitor contains as an active ingredient, cataract preventing or treating agent.
[claim2]
2. The HAT, HAT1,NAA60,GCN5,PCAF,TIP60,MOZ,MORF,HBO1,MOF,P300,CBP,TAF1,TIFIIIC90,SRC1,SCR3,P600,CLOCK inhibitor is selected from the group consisting of 1 NAT10 and the one or more materials are targeted, according to claim 1 cataractogenisis preventing or treating agent.
[claim3]
3. The HAT inhibitors, polyphenol derived compound, in the structure and a heterocyclic ring is a compound comprising, benzoic acid derivatives, or α - β unsaturated carbonyl compound, according to claim 1 or 2 cataractogenisis preventing or treating agent.
[claim4]
4. The HAT inhibitors, curcumin, 2,6 - bis (-3 - - bromo - -4 - hydroxy benzylidene malonate) cyclohexane, CTK7A, Epigenetic Multiple Ligand, garcinol, -2 - - chloro - -3 (4-- nitrophenyl) anacardic, MG149,C646,NU9056,CPTH2,5- acid (2H) -isothiazolone, butyrolactone 3, gallic acid, (-) -epigallocatechin, EML425, L002, ISOX DUAL, plumbagin, TH1834,SPV106,Windorphen, ketomin, Remodelin, enberin, Ischemin, CBP30 KG501 and 1 is selected from the group consisting of the one or more materials, or a salt or a derivative or the material, according to claim 1 or 2 cataractogenisis preventing or treating agent.
[claim5]
5. If the dosage is eyedrops, cataract of any one of claims 1-4 1 preventing or treating agent.
[claim6]
6. The above-mentioned Cataracts are, cataract in diabetes, cataract of any one of claims 1-5 1 preventing or treating agent.
[claim7]
7. Preventing or treating a cataractogenisis for manufacture, use of inhibitors of HAT.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • UNIVERSITY OF FUKUI
  • Inventor
  • OKI MASAYA
  • KANADA FUMITO
  • TAKAMURA YOSHIHIRO
  • MIYAKE SEIJI
  • UCHIDA HIROYUKI
IPC(International Patent Classification)
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