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CHOLINE ESTER-CONTAINING COMPOSITION FOR ORAL INGESTION コモンズ

外国特許コード F180009455
整理番号 (L16005)
掲載日 2018年7月25日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP037389
国際公開番号 WO 2018070545
国際出願日 平成29年10月16日(2017.10.16)
国際公開日 平成30年4月19日(2018.4.19)
優先権データ
  • 特願2016-202909 (2016.10.14) JP
発明の名称 (英語) CHOLINE ESTER-CONTAINING COMPOSITION FOR ORAL INGESTION コモンズ
発明の概要(英語) The present invention addresses the problem of providing a composition that contains a choline ester such as acetylcholine as an active ingredient, can be orally ingested by humans by a simple method, and has a blood pressure-lowering effect and/or anti-stress effect. The present invention also addresses the problem of providing: a novel orally-ingestible composition that enables humans to ingest a choline ester such as acetylcholine in a simple method and has a blood pressure-lowering effect and a vasodilating effect; and food products that provide useful supply sources for such a composition.
従来技術、競合技術の概要(英語) BACKGROUND ART
In the choline ester, mammalian as a neurotransmitter acetylcholine is essential to life activities are known to be material. In addition, in the year 1929, the release of histamine from a blood pressure drop in the equine spleen is different from the isolated material, the active material is chemically acetylcholine (non-patent document 1) has been identified. Further, ergot blood pressure lowering material is solved in the acetylcholine, fungi and bacteria produce acetylcholine has been confirmed (non-patent document 2). Acetylcholine, edible plants, edible fungi, royal jelly, and the like contained in the milk, Bacillus subtilis, acetylcholine is present in the yeast, edible plants, plant and bamboo-shoot of the high content of acetylcholine have been reported (Non-Patent Document 3-7).
In addition, other of acetylcholine, a plurality of choline esters have been discovered. Acetyl group and propionyl group 1 consisting of a carbon chain having one long propionyloxy colin is, 1953 years have been discovered from the spleen of cattle (non-patent document 8, 9). Then, in the bovine semen buck, crayfish Europe, America swordtail, europe colander guy, oonogai, mussels avelana, hondobugai, in the smooth muscle and blood lymphocytes in the apple snail, torpedo other electricity generator in tissue culture, hen'youboku, green beans, psyllium, poplar, birch and the like in, propionyloxy colin confirmed production (non-patent document 10-13).
Also, butyrylcholine will be, from the brain extracts found in the year 1954 (Non-Patent Document 14), an arthropod, in mollusks, acetylcholine, propionyloxy colin are shown to be present together with the (non-patent document 11). Further, propionyloxy colin, butyrylcholine other than from molluskan, some confirmed choline esters. For example, is one of the following akukigai paulo kano il colin, β β - dimethyl acroyl colin reishigai (sene shea oil colin) is of one selected from the group, acroyl colin buccinid is one of the following, the structure of one of the imidazole propionyloxy colin reishigai determined (non-patent document 15-18).
The present inventors, the fermentation (fermentation plant sarrazin lactic acid) kyoubaku included in the effect of lowering blood pressure and blood vessel expansion were studied active ingredient, at least comprising acetylcholine propionyloxy colin, a plurality of choline ester quaternary alkylammonium compound mainly containing the first extracted 4 to provide a composition, the acetylcholine was purified, propionyloxy colin, the (SHR) to spontaneously hypertensive rats butyrylcholine single oral administration of the blood pressure lowering effect was revealed (Patent Document 1, 2). On the other hand, the pharmaceutical active ingredient of acetylcholine chloride (non-patent document 19) in the form of an interview, ' digestive tract in the oral administration of acetylcholine is degraded, since it is not substantially absorbed, and the injections' as described in the, it is applied to human choline ester due to the injection pressure is applied to the ingestion has not been studied.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • SHINSHU UNIVERSITY
  • 発明者(英語)
  • NAKAMURA, Kozo
国際特許分類(IPC)
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